VPS34 (Kr.18q12.3), PI3C3 , fosfatidyyli-inositoli-3-kinaasi alayksikkö tyyppi 3.

VPS34 (Kr.18q12.3) , PI3KC3 ,

fosfatidyyli-inositoli-3-kinaasi katalyyttinen alayksikkö tyyppi 3 

https://www.ncbi.nlm.nih.gov/gene/5289

Also known as VPS34; Vps34; hVps34

Expression Ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues See more Orthologs mouse all

Preferred Names

phosphatidylinositol 3-kinase catalytic subunit type 3

Names

PI3-kinase type 3

PI3K type 3

PtdIns-3-kinase type 3

phosphatidylinositol 3-kinase p100 subunit

phosphoinositide-3-kinase, class 3

NP_001294949.1

• EC 2.7.1.137

NP_002638.2

• EC 2.7.1.137

XP_011524333.1

• EC 2.7.1.137

Conserved domains

Conserved Domains (3) summary

cd08397
Location:24 → 123

C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)

cd00870
Location:220 → 440

PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...

cd00896
Location:476 → 820

PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

Peptide sequence and history

https://www.ncbi.nlm.nih.gov/protein/NP_001294949.1
Kts. Myös geeni: https://en.wikipedia.org/wiki/ZFYVE1

Related articles in PubMed

1. Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling. Uchida Y, et al. Mol Pharmacol, 2017 Jan. PMID 27821547, Free PMC Article
2. Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors. Pasquier B, et al. J Med Chem, 2015 Jan 8. PMID 25402320
3. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Yuan HX, et al. Autophagy, 2013 Dec. PMID 24013218, Free PMC Article
4. Promoter variant of PIK3C3 is associated with autoimmunity against Ro and Sm epitopes in African-American lupus patients. Kariuki SN, et al. J Biomed Biotechnol, 2010. PMID 20671926, Free PMC Article
5. Activation of PI3K-AKT pathway in oral epithelial dysplasia and early cancer of tongue. Watanabe S, et al. Bull Tokyo Dent Coll, 2009 Aug. PMID 19887755
   

See all (155) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Vps34 stimulates tumor development mainly through PKC-delta- activation of p62.
2. Here we show that a putative fifth subunit, nuclear receptor binding factor 2 (NRBF2), is a tightly bound component of the class III phosphatidylinositol 3-kinase complex I that profoundly affects its activity and architecture. NRBF2 is a homodimer and drives the dimerization of the larger PI3KC3-C1 complex, with implications for the higher-order organization of the preautophagosomal structure.
3. This study reveals NRBF2 as a critical molecular switch of PtdIns3K and autophagy activation, and its on/off state is precisely controlled by MTORC1 through phosphorylation.
4. Atg38 and its human ortholog NRBF2, accessory components of complex I consisting of Vps15-Vps34-Vps30/Atg6-Atg14 (yeast) and PIK3R4/VPS15-PIK3C3/VPS34-BECN1/Beclin 1-ATG14 (human), were characterized.
5. p300-dependent VPS34 acetylation/deacetylation is the physiological key to VPS34 activation, which controls the initiation of canonical autophagy and of non-canonical autophagy in which the upstream kinases of VPS34 can be bypassed.
6. Low VPS34 expression is associated with cancer.
7. Arf tumor suppressor as a new transcriptional target of nuclear EGFR and highlight Vps34 as an important regulator of the nuclear EGFR/Arf survival pathway.
8. Vps34 has a previously unknown role in regulating Rab7 activity and late endosomal trafficking.
9. High expression of VPS34 promoted GRP78 transcription by modulating ATF6. VPS34 could enhance GRP78 protein stability.
10. These results establish Vps34 as an essential determinant of both short-term and long-term canonical GPCR signaling.
    

Submit: New GeneRIF Correction See all GeneRIFs (53)

https://www.ncbi.nlm.nih.gov/gene/5289#