ESCRT-1, VPS37C (Kr.11q12.2)

ESCRT-1, VPS37C

https://www.ncbi.nlm.nih.gov/gene/55048

Preferred Names

vacuolar protein sorting-associated protein 37C

Names

ESCRT-I complex subunit VPS37C

hVps37C

vacuolar protein sorting 37 homolog C

vacuolar protein sorting 37C

Conserved Domains (2)

pfam07200
Location:5 → 149

Mod_r; Modifier of rudimentary (Mod(r)) protein

cl26464
Location:184 → 313

Atophin-1;r Atrophin-1 family

PEPTIDE sequence 355 a.a.

https://www.ncbi.nlm.nih.gov/protein/NP_001348888.1

Modifier of rudimentary (Mod(r)) protein ( 5..146 Mod_r)

This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic, and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors

ORIGIN      
        1 metlkdktlq eleelqndse aidqlalesp evqdlqlere malatnrsla ernlefqgpl
       61 eisrsnlsdr yqelrklver cqeqkaklek fssalqpgtl ldllqvegmk ieeeseamae
      121 kflegevple tflenfssmr mlshlrrvrv eklqevvrkp rasqelagda ppprppppvr
      181 pvpqgtppvv eeqpqpplam ppyplpysps pslpvgptah galppapfpv vsqpsfysgp
      241 lgptypaaql gprgaagysw spqrsmpprp gypgtpmgas gpgyplrggr apspgypqqs
      301 pypatggkpp ypiqpqlpsf pgqpqpsvpl qppyppgpap pygfppppgp awpgy

Related articles in PubMed

1. The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. Wunderley L, et al. J Cell Sci, 2014 Feb 1. PMID 24284069, Free PMC Article
2. Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. Eastman SW, et al. J Biol Chem, 2005 Jan 7. PMID 15509564
3. VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I. Okumura M, et al. Biosci Biotechnol Biochem, 2013. PMID 23924735
4. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Agromayor M, et al. Structure, 2012 Mar 7. PMID 22405001, Free PMC Article
5. UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Stefani F, et al. Curr Biol, 2011 Jul 26. PMID 21757351