ESCRT-1, VPS37D (Kr. 7q11.23), WBSCR24

ESCRT-1,VPS37D WBSCR24 

https://www.ncbi.nlm.nih.gov/gene/155382

Also known WBSCR24

Expression

Broad expression in kidney (RPKM 3.2), brain (RPKM 1.6) and 20 other tissues See more

Orthologs

mouse all

Preferred Names

vacuolar protein sorting-associated protein 37D

Names

ESCRT-I complex subunit VPS37D

Williams Beuren syndrome chromosome region 24

Williams-Beuren syndrome critical region protein 24

vacuolar protein sorting 37 homolog D

vacuolar protein sorting 37D

williams-Beuren syndrome chromosomal region 24 protein

williams-Beuren syndrome region protein 24

Peptide sequence

https://www.ncbi.nlm.nih.gov/protein/NP_001071089.1

Conserved Domains (2) summary

pfam04503
Location:179 → 251

SSDP; Single-stranded DNA binding protein, SSDP

pfam07200
Location:22 → 164

Mod_r; Modifier of rudimentary (Mod(r)) protein

ORIGIN 1 myraraarag pepgspgrfg ilstgqlrdl lqdepkldri vrlsrkfqgl qlereaclas 61 nyalakenla lrprlemgra alaikyqelr evaencadkl qrleesmhrw sphcalgwlq 121 aeleeaeqea eeqmeqlllg eqsleaflpa fqrgralahl rrtqaeklqe llrrrersaq 181 paptsaadpp ksfpaaavlp tgaargppav prslppldsr pvpplkgspg cplgpaplls 241 prpsqpepph r //

Related articles in PubMed

1. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Agromayor M, et al. Structure, 2012 Mar 7. PMID 22405001, Free PMC Article
2. The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. Stuchell MD, et al. J Biol Chem, 2004 Aug 20. PMID 15218037
3. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. Morita E, et al. EMBO J, 2007 Oct 3. PMID 17853893, Free PMC Article Abstract

TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular body (MVB), where they interact with other Endosomal Sorting Complex Required for Transport (ESCRT) pathway factors required for release of viruses and vesicles. Proteomic analyses revealed that ALIX and TSG101/ESCRT-I also bind a series of proteins involved in cytokinesis, including CEP55, CD2AP, ROCK1, and IQGAP1. ALIX and TSG101 concentrate at centrosomes and are then recruited to the midbodies of dividing cells through direct interactions between the central CEP55 'hinge' region and GPP-based motifs within TSG101 and ALIX. ESCRT-III and VPS4 proteins are also recruited, indicating that much of the ESCRT pathway localizes to the midbody. Depletion of ALIX and TSG101/ESCRT-I inhibits the abscission step of HeLa cell cytokinesis, as does VPS4 overexpression, confirming a requirement for these proteins in cell division. Furthermore, ALIX point mutants that block CEP55 and CHMP4/ESCRT-III binding also inhibit abscission, indicating that both interactions are essential. These experiments suggest that the ESCRT pathway may be recruited to facilitate analogous membrane fission events during HIV budding, MVB vesicle formation, and the abscission stage of cytokinesis.

3. Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Coffee and Caffeine Genetics Consortium., et al. Mol Psychiatry, 2015 May. PMID 25288136, Free PMC Article
4. Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Morita E, et al. Cell Host Microbe, 2007 Jul 12. PMID 18005716, Free PMC Article