https://www.ncbi.nlm.nih.gov/gene/143662
- Also known as
- PAS3; MUC-15; PASIII
- Expression: Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues
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- https://www.ncbi.nlm.nih.gov/protein/NP_001128563.1
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Frameshift mutations of MUC15 gene in gastric and its regional heterogeneity in gastric and colorectal cancers.
Oh HR, et al. Pathol Oncol Res, 2015 Jul. PMID 25573589
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Correlations of MUC15 overexpression with clinicopathological features and prognosis of glioma.
Yang WB, et al. J Huazhong Univ Sci Technolog Med Sci, 2014 Apr. PMID 24710941
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MUC15
inhibits dimerization of EGFR and PI3K-AKT signaling and is associated
with aggressive hepatocellular carcinomas in patients.
Wang RY, et al. Gastroenterology, 2013 Dec. PMID 23933603
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Overexpression
of MUC15 activates extracellular signal-regulated kinase 1/2 and
promotes the oncogenic potential of human colon cancer cells.
Huang J, et al. Carcinogenesis, 2009 Aug. PMID 19520792
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Mucin 15 is expressed in human placenta and suppresses invasion of trophoblast-like cells in vitro.
Shyu MK, et al. Hum Reprod, 2007 Oct. PMID 17720698
- GeneRif
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Frameshift mutations of MUC15 gene is associated with gastric and colorectal cancers.
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Multivariate
analysis suggested that MUC15 overexpression was an independent factor
for prognosis (hazard risk: 3.216; P=0.009). It was concluded that MUC15
is overexpressed in glioma tissues.
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MUC15
inhibits dimerization of EGFR and PI3K-AKT signaling and is associated
with aggressive hepatocellular carcinomas in patients.
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MUC15 is a strong candidate for eczema.
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MUC4
and MUC15 were overexpressed in papillary thyroid carcinoma, and high
MUC15 expression was associated with high malignant potential.
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Overexpression
of MUC15 activates extracellular signal-regulated kinase 1/2 and
promotes the oncogenic potential of colon cancer cells.
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Reflux laryngitis is associated with down-regulation of mucin gene expression.
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MUC15
was expressed most highly in human placenta. MUC15 mRNA & protein
increased with gestational age (P < 0.05, 1st versus 3rd trimester).
Differential expression of MUC15 in human placentas may play critical
role in regulation of trophoblast invasion.
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