ZBTB35( 5p12), ZNF131, pHZ-10. https://www.ncbi.nlm.nih.gov/gene/7690
- Official Symbol
- ZNF131
- Official Full Name
- zinc finger protein 131
- Also known as
- ZBTB35; pHZ-10
- Expression
- Ubiquitous expression in testis (RPKM 10.2), bone marrow (RPKM 5.2) and 25 other tissues See more
- Orthologs mouse all
-
NM_001297548.2 → NP_001284477.1 zinc finger protein 131 isoform 1
See identical proteins and their annotated locations for NP_001284477.1
Status: VALIDATED- Description
- Transcript Variant: This variant (1) encodes the longest isoform (1).
- Conserved Domains (6) summary
-
- smart00225
Location:35 → 122 - BTB; Broad-Complex, Tramtrack and Bric a brac
- COG5048
Location:262 → 444 - COG5048; FOG: Zn-finger [General function prediction only]
- sd00017
Location:290 → 311 - ZF_C2H2; C2H2 Zn finger [structural motif]
- sd00019
Location:422 → 439 - ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam00651
Location:24 → 122 - BTB; BTB/POZ domain
- pfam13465
Location:342 → 367 - zf-H2C2_2; Zinc-finger double domain
- smart00225
- Ref.
- High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. Han X, et al. BMC Genomics, 2008 Oct 11. PMID 18847501, Free PMC Article
- ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5. Ding Y, et al. Oncotarget, 2017 Jul 25. PMID 28596487, Free PMC Article
- Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization. Oh Y, et al. Biochem Biophys Res Commun, 2013 Jan 4. PMID 23159625
- The murine BTB/POZ zinc finger gene Znf131: predominant expression in the developing central nervous system, in adult brain, testis, and thymus. Trappe R, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163020
- Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. Oh Y, et al. J Biol Chem, 2012 May 18. PMID 22467880, Free PMC Article .. Here, we identify ZNF131 as a target for SUMO modification and as a substrate for the SUMO E3 ligase human polycomb protein 2 (hPc2).
- Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability.
- identify a novel substoichiometric interactor of the complex, transcription factor ZNF131, which recruits EMSY to a large number of active, H3K4me3 marked promoters.
- UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131
- these data suggest that ZNF131 inhibits estrogen signaling by acting as an ERalpha-co-repressor.
- SUMOylation is a novel regulator of ZNF131 action in estrogen signaling and breast cancer cell proliferation.
- Interaction between ZNF131 and ERalpha interrupts or prevents ERalpha binding to the estrogen response element. ZNF131 also suppresses the expression of TFF1.
- The mechanism of Znf131 nuclear localization, is reported. .. BR-1 and BR-2 are functional NLSs for Znf131 and as such are designated NLS-1 and NLS-2. Finally, wild type Znf131, and not a Znf131 NLS-defective mutant (NLS-1m/NLS-2m) interacted preferentially with the nuclear import receptor Importin-alpha3 in vitro.
