FIGURE 7
Figure 7. A schematic diagram illustrating the interplay
between TLX and the BMP-SMAD signaling pathway in the regulation of
neurogenesis and astrogenesis. TLX directly modulates the
expression of the BMP ligands, which bind and activate the type I (RI)
and type II (RII) receptors. These events result in phosphorylation of
regulatory SMADs and their dimerization with the common cofactor SMAD4.
The SMAD complex acts as a transcriptional activator to induce the
expression of downstream targets, which promote astrogenesis and inhibit
neurogenesis.