Kelch-like protein 32 (KLHL32) belongs to the KLHL family
[1]. Its function is not clear.
The
KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK
domain, and five to six Kelch motifs. They constitute a subgroup at the
intersection between the BTB/POZ domain and Kelch domain superfamilies.
The BTB/POZ domain facilitates protein binding
[1],
while the Kelch domain (repeats) form beta-propellers. The Kelch
superfamily of proteins can be subdivided into five groups:
(1)
N-propeller, C-dimer proteins,
(2) N-propeller proteins,
(3) propeller
proteins,
(4) N-dimer, C-propeller proteins, and
(5) C-propeller
proteins.
KLHL family members belong to the N-dimer, C-propeller
subclass of Kelch repeat proteins [2]
.
In addition to BTB/POZ and Kelch domains, the KLHL family members
contain a BACK domain, first described as a 130-residue region of
conservation observed amongst BTB-Kelch proteins
[3].
Many of the Kelch-like proteins have been identified as adaptors for
the recruitment of substrates to Cul3-based E3 ubiquitin ligases [4, 5]
