ESCRT-I, TSG101 (Kr.11p15.1), TSG10, VPS23, Tumorsusceptibility gene 101

ESCRT-1

TSG101 Tumor suspectibility gene 101, VPS101

https://www.ncbi.nlm.nih.gov/gene/7251

Also known as TSG10; VPS23

Summary. The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in testis (RPKM 34.7), adrenal (RPKM 31.6) and 25 other tissues See more Orthologs mouse all

Preferred Names

tumor susceptibility gene 101 protein

Names

ESCRT-I complex subunit TSG101

tumor susceptibility gene 10

tumor susceptibility gene 101

tumor susceptibility protein

Conserved Domains (4) summary

PHA03369
Location:93 → 323

PHA03369; capsid maturational protease; Provisional

pfam05743
Location:21 → 139

UEV; UEV domain

pfam07798
Location:236 → 292

DUF1640; Protein of unknown function (DUF1640)

pfam09454
Location:316 → 375

Vps23_core; Vps23 core domain

Peptide sequence , 1-390 a.a.

 320..323: PTAP-motif;  plenty of tyrosinyls (y).

https://www.ncbi.nlm.nih.gov/protein/NP_006283.1

ORIGIN      
        1 mavsesqlkk mvskykyrdl tvretvnvit lykdlkpvld syvfndgssr elmnltgtip
       61 vpyrgntyni piclwlldty pynppicfvk ptssmtiktg khvdangkiy lpylhewkhp
      121 qsdllgliqv mivvfgdepp vfsrpisasy ppyqatgppn tsympgmpgg ispypsgypp
      181 npsgypgcpy ppggpypatt ssqypsqppv ttvgpsrdgt isedtirasl isavsdklrw
      241 rmkeemdraq aelnalkrte edlkkghqkl eemvtrldqe vaevdkniel lkkkdeelss
      301 alekmenqse nndideviip taplykqiln lyaeenaied tifylgealr rgvidldvfl
      361 khvrllsrkq fqlralmqka rktaglsdly

Related articles in PubMed

1. TSG101 Silencing Suppresses Hepatocellular Carcinoma Cell Growth by Inducing Cell Cycle Arrest and Autophagic Cell Death. Shao Z, et al. Med Sci Monit, 2015 Nov 5. PMID 26537625, Free PMC Article
2. Gene and protein expression in the oxaliplatin-resistant HT29/L-OHP human colon cancer cell line. Xiang Z, et al. Genet Mol Res, 2015 Sep 21. PMID 26400331
3. Functional Interaction Between the ESCRT-I Component TSG101 and the HSV-1 Tegument Ubiquitin Specific Protease. Calistri A, et al. J Cell Physiol, 2015 Aug. PMID 25510868
4. Interaction with Tsg101 is necessary for the efficient transport and release of nucleocapsids in marburg virus-infected cells. Dolnik O, et al. PLoS Pathog, 2014 Oct. PMID 25330247, Free PMC Article
5. Human papillomavirus infection requires the TSG101 component of the ESCRT machinery. Broniarczyk J, et al. Virology, 2014 Jul. PMID 25010273
   

See all (272) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag.
2. our studies reveal that Tsg101 plays a role in the trafficking of macropinocytosed Kaposi's sarcoma-associated herpesvirus in the endothelial cells
3. Knockdown of LAMP2A, a CMA-related protein, and TSG101, an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH-HT in AD293 cells and primary cultured rat cortical neurons.
4. the variant alleles of TSG101 rs2292179 and ATF2 rs3845744 were associated with a reduced risk of breast cancer, particularly for subjects with BMI <24 a="" and="" kg="" m="" postmenopausal="" respectively="" women="">
5. TSGDelta154-1054 splice variant increases TSG101 oncogenicity by inhibiting its E3-ligase-mediated proteasomal degradation.
6. Results show that TSG101 bidirectionally modulates cell invasion through regulating MMP-9 mRNA expression in different cell types.
7. TSG101 plays an important role in the development of hepatocellular carcinoma
8. Expression of tsg101 mRNA and of TSG101 protein were significantly higher in the oxaliplatin resistant cell line than parent HT-29 cels.
9. PSAP motif of OFR3 is required for hepatitis E virus exit and interaction with host TSG101.
10. Stress-internalized EGFR is retained intracellularly by continued p38 activity in a mechanism involving ubiquitin-independent, ESCRT/ALIX-dependent incorporation onto intraluminal vesicles (ILVs) of MVBs
    

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