ESCRT-II , EAP30 (Kr.17q21.32), VPS22, SNF8, Dot3

ESCRT-II Complex EAP30

 Geenin viralliseksi nimeksi on päätetty SNF8.

https://www.ncbi.nlm.nih.gov/gene/11267

Also known as

Dot3; EAP30; VPS22

Summary The protein encoded by this gene is a component of the endosomal sorting complex required for transport II (ESCRT-II), which regulates the movement of ubiquitinylated transmembrane proteins to the lysosome for degradation. This complex also interacts with the RNA polymerase II elongation factor (ELL) to overcome the repressive effects of ELL on RNA polymerase II activity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] Expression

Ubiquitous expression in kidney (RPKM 18.5), fat (RPKM 18.4) and 25 other tissues See more Orthologs mouse all

Preferred Names

vacuolar-sorting protein SNF8

Names

EAP30 subunit of ELL complex

ELL-associated protein of 30 kDa

ESCRT-II complex subunit VPS22

SNF8, ESCRT-II complex subunit, homolog

EAP30/Vps36 family

This family includes EAP30 as well as the Vps36 protein. Vps36 is involved in Golgi to endosome trafficking. EAP30 is a subunit of the ELL complex. The ELL is an 80-kDa RNA polymerase II transcription factor. ELL interacts with three other proteins to form the complex known as ELL complex. The ELL complex is capable of increasing that catalytic rate of transcription elongation, but is unable to repress initiation of transcription by RNA polymerase II as is the case of ELL. EAP30 is thought to lead to the derepression of ELL's transcriptional inhibitory activity.

Peptide sequence

https://www.ncbi.nlm.nih.gov/protein/NP_001304121.1

Related articles in PubMed

1. Differential functions of Hrs and ESCRT proteins in endocytic membrane trafficking. Raiborg C, et al. Exp Cell Res, 2008 Feb 15. PMID 18031739
2. Pivotal role for the ESCRT-II complex subunit EAP30/SNF8 in IRF3-dependent innate antiviral defense. Kumthip K, et al. PLoS Pathog, 2017 Oct. PMID 29084253, Free PMC Article
3. Inhibition of ESCRT-II-CHMP6 interactions impedes cytokinetic abscission and leads to cell death. Goliand I, et al. Mol Biol Cell, 2014 Nov 15. PMID 25232011, Free PMC Article
4. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. Erbilgin A, et al. J Lipid Res, 2013 Jul. PMID 23667179, Free PMC Article
5. RILP interacts with the VPS22 component of the ESCRT-II complex. Progida C, et al. Biochem Biophys Res Commun, 2006 Sep 8. PMID 16857164
   

See all (46) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. data describe an unappreciated role for EAP30 in IRF3-dependent innate antiviral response in the nucleus.
2. Taken together, these data suggest an active role for ESCRT-II and CHMP6 in ESCRT-mediated abscission
3. Modulating SNF8 expression levels alters the TRPC6 channel current and can modulate activation of NFAT-mediated transcription downstream of gain-of-function mutant TRPC6.
4. Vps22 has an important role in ligand-induced EGFR and CXCR4 turnover; termination of EGF signaling occurs prior to ESCRT-II engagement
5. mammalian ESCRTII is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body
6. there are probably multiple pathways for protein sorting/multivesicular body vesicle formation in human cells and that human immunodeficiency virus type 1 does not utilize an ESCRT-II-dependent pathway to leave the cell