https://www.ncbi.nlm.nih.gov/gene/51652
- Preferred Names
- charged multivesicular body protein 3
- Names
- 25.1 protein
- CHMP family, member 3
- chromatin-modifying protein 3
- neuroendocrine differentiation factor
- vacuolar protein sorting 24 homolog
- vacuolar protein sorting-associated protein 24
- Also known as
- NEDF; VPS24; CGI-149
- Summary
- This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]
- Expression
- Ubiquitous expression in esophagus (RPKM 41.6), thyroid (RPKM 40.0) and 25 other tissues See more
- Readthrough gene: RNF103-CHMP3, Included gene: RNF103
- RAKENNE: isoformi2
- https://www.ncbi.nlm.nih.gov/protein/NP_001005753.1
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