- cd04021
Location:17 → 140
- C2_E3_ubiquitin_ligase; C2 domain present in E3 ubiquitin ligase
- COG5021
Location:307 → 922
- HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
LOCUS NP_008944 922 aa linear PRI 01-APR-2018
DEFINITION NEDD4-like E3 ubiquitin-protein ligase WWP1 [Homo sapiens].
ACCESSION NP_008944 XP_005250816
VERSION NP_008944.1
DBSOURCE REFSEQ: accession NM_007013.3
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 922)
AUTHORS Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO,
Freedman BD, Bedford MT, Sidhu SS, Sudol M and Harty RN.
TITLE Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate
Egress
JOURNAL J. Virol. 91 (20), e00812-17 (2017)
PUBMED 28768865
REMARK GeneRIF: study describes a physical and functional interaction
between Ebola virus VP40 (eVP40) and WWP1, a host E3 ubiquitin
ligase that ubiquitinates VP40 and regulates virus-like particles
egress.
Publication Status: Online-Only
REFERENCE 2 (residues 1 to 922)
AUTHORS French ME, Klosowiak JL, Aslanian A, Reed SI, Yates JR 3rd and
Hunter T.
TITLE Mechanism of ubiquitin chain synthesis employed by a HECT domain
ubiquitin ligase
JOURNAL J. Biol. Chem. 292 (25), 10398-10413 (2017)
PUBMED 28461335
REMARK GeneRIF: results demonstrate that WWP1 catalyzes the formation of
Ub chains through a sequential addition mechanism, in which Ub
monomers are transferred in a successive fashion to the substrate,
and that ubiquitination by WWP1 requires the presence of a
low-affinity, noncovalent Ub-binding site within the HECT domain.
REFERENCE 3 (residues 1 to 922)
AUTHORS Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P,
Wolberger C, Amzel LM, Gabelli SB and Cole PA.
TITLE A Tunable Brake for HECT Ubiquitin Ligases
JOURNAL Mol. Cell 66 (3), 345-357 (2017)
PUBMED 28475870
REMARK GeneRIF: Describe an autoinhibitory mechanism for WWP1 ubiquitin
ligase involving a linker-HECT domain interaction. This
intramolecular interaction traps the HECT enzyme in its inactive
state and can be relieved by linker phosphorylation.
REFERENCE 4 (residues 1 to 922)
AUTHORS Li Q, Li Z, Wei S, Wang W, Chen Z, Zhang L, Chen L, Li B, Sun G, Xu
J, Li Q, Wang L, Xu Z, Xia Y, Zhang D, Xu H and Xu Z.
TITLE Overexpression of miR-584-5p inhibits proliferation and induces
apoptosis by targeting WW domain-containing E3 ubiquitin protein
ligase 1 in gastric cancer
JOURNAL J. Exp. Clin. Cancer Res. 36 (1), 59 (2017)
PUBMED 28431583
REMARK GeneRIF: Results show that WWP1 is frequently upregulated in
gastric cancer (GC) tissues and cells, and that its 3'-UTR is a
putative target of miR-584 which suppresses its protein expression
by mRNA degradation.
Publication Status: Online-Only
REFERENCE 5 (residues 1 to 922)
AUTHORS Chen J, Shi H, Chen Y, Fan S, Liu D and Li C.
TITLE DNA damage induces expression of WWP1 to target DeltaNp63alpha to
degradation
JOURNAL PLoS ONE 12 (4), e0176142 (2017)
PUBMED 28426804
REMARK GeneRIF: Knock-down of WWP1 abrogates DNA damage-induced
down-regulation of DeltaNp63alphaand partially rescues cell
apoptosis
Publication Status: Online-Only
REFERENCE 6 (residues 1 to 922)
AUTHORS Flasza M, Gorman P, Roylance R, Canfield AE and Baron M.
TITLE Alternative splicing determines the domain structure of WWP1, a
Nedd4 family protein
JOURNAL Biochem. Biophys. Res. Commun. 290 (1), 431-437 (2002)
PUBMED 11779188
REFERENCE 7 (residues 1 to 922)
AUTHORS Conkright MD, Wani MA and Lingrel JB.
TITLE Lung Kruppel-like factor contains an autoinhibitory domain that
regulates its transcriptional activation by binding WWP1, an E3
ubiquitin ligase
JOURNAL J. Biol. Chem. 276 (31), 29299-29306 (2001)
PUBMED 11375995
REFERENCE 8 (residues 1 to 922)
AUTHORS Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA and Bresnick EH.
TITLE Physical and functional interactions between the transactivation
domain of the hematopoietic transcription factor NF-E2 and WW
domains
JOURNAL Biochemistry 37 (39), 13686-13695 (1998)
PUBMED 9753456
REFERENCE 9 (residues 1 to 922)
AUTHORS Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky
Z, Kleiderlein JJ, Sharp AH and Ross CA.
TITLE Atrophin-1, the DRPLA gene product, interacts with two families of
WW domain-containing proteins
JOURNAL Mol. Cell. Neurosci. 11 (3), 149-160 (1998)
PUBMED 9647693
REFERENCE 10 (residues 1 to 922)
AUTHORS Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK
and Fowlkes DM.
TITLE Identification of novel human WW domain-containing proteins by
cloning of ligand targets
JOURNAL J. Biol. Chem. 272 (23), 14611-14616 (1997)
PUBMED 9169421
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
BC036065.1, AY043361.1, BM664090.1 and AW137654.1.
On Aug 31, 2013 this sequence version replaced XP_005250816.1.
Summary: WW domain-containing proteins are found in all eukaryotes
and play an important role in the regulation of a wide variety of
cellular functions such as protein degradation, transcription, and
RNA splicing. This gene encodes a protein which contains 4 tandem
WW domains and a HECT (homologous to the E6-associated protein
carboxyl terminus) domain. The encoded protein belongs to a family
of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and
regulate key trafficking decisions, including targeting of proteins
to proteosomes or lysosomes. Alternative splicing of this gene
generates at least 6 transcript variants; however, the full length
nature of these transcripts has not been defined. [provided by
RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660803.42287.1,
SRR1660803.74219.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682
[ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..922
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="8"
/map="8q21.3"
Protein 1..922
/product="NEDD4-like E3 ubiquitin-protein ligase WWP1"
/EC_number="2.3.2.26"
/note="Nedd-4-like ubiquitin-protein ligase; atrophin-1
interacting protein 5; TGIF-interacting ubiquitin ligase
1; WW domain-containing protein 1; HECT-type E3 ubiquitin
transferase WWP1"
/calculated_mol_wt=105071
Region 17..140
/region_name="C2_E3_ubiquitin_ligase"
/note="C2 domain present in E3 ubiquitin ligase; cd04021"
/db_xref="CDD:175988"
Region <307 ..922="" cdd="" cddsrv.cgi="" db_xref="CDD:<a href=" https:="" note="Ubiquitin-protein ligase [Posttranslational
modification, protein turnover, chaperones]; COG5021" region_name="HUL4" tructure="" uid="227354" www.ncbi.nlm.nih.gov="">227354
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