ESCRT-II, EAP20, (Kr.17q21.2), VPS25, DERP9, FAP20

ESCRT-II

( EAP20  geenin virallinen nimi on nyt VPS25)

Vacuolar protein sorting 25, human
https://www.ncbi.nlm.nih.gov/gene/84313

Also known as DERP9; EAP20; FAP20

Summary This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on chromosome 1. [provided by RefSeq, Jul 2013]

Expression Ubiquitous expression in esophagus (RPKM 14.2), colon (RPKM 12.6) and 25 other tissues See more

Orthologs mouse all

Preferred Names

vacuolar protein-sorting-associated protein 25

Names

ELL-associated protein of 20 kDa

ESCRT-II complex subunit VPS25

dermal papilla-derived protein 9

https://www.cell.com/cms/attachment/2119039383/2088388025/gr2.jpg

Conserved Domains (1) summary

pfam05871
Location:10 → 145 ESCRT-II; ESCRT-II complex subunit

Peptide sequence

vacuolar protein-sorting-associated protein 25 [Homo sapiens]

NCBI Reference Sequence: NP_115729.1

https://www.ncbi.nlm.nih.gov/protein/NP_115729.1

Related articles in PubMed

1. Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Im YJ, et al. Dev Cell, 2009 Aug. PMID 19686684, Free PMC Article
2. Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. Sharma M, et al. J Cell Biol, 2004 Mar 15. PMID 15007060, Free PMC Article
3. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. Yorikawa C, et al. Biochem J, 2005 Apr 1. PMID 15511219, Free PMC Article
4. Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Im YJ, et al. Dev Cell, 2008 Jun. PMID 18539118, Free PMC Article
5. Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production. Meng B, et al. Retrovirology, 2015 Aug 14. PMID 26268989, Free PMC Article
   

See all (35) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
2. Observational study of gene-disease association. (HuGE Navigator)
3. Results describe the mapping of multivesicular bodies with the second winged helix domain of human ESCRT-II subunit VPS25 and the first helix of ESCRT-III subunit VPS20.
4. mammalian ESCRTII is made up of hVps25p, hVps22p, and hVps36p and may be redundant, cargo-specific, or not required for protein sorting at the multivesicular body
   

Muistiin 17.5. 2018