ESCRT-0, STAM1, (Kr.10p12.33), HSE1, (SH3 domeeni ja ITAM motiivi)

ESCRT-0, STAM1 (Kr.10p12.33), HSE1 , SH3 domeeni ja ITAM motiivi

https://www.ncbi.nlm.nih.gov/gene/8027

Also known as STAM1; STAM-1

Summary This gene encodes a member of the signal-transducing adaptor molecule family. These proteins mediate downstream signaling of cytokine receptors and also play a role in ER to Golgi trafficking by interacting with the coat protein II complex. The encoded protein also associates with hepatocyte growth factor-regulated substrate (HRS) to form the endosomal sorting complex required for transport-0 (ESCRT-0), which sorts ubiquitinated membrane proteins to the ESCRT-1 complex for lysosomal degradation. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]

Expression Ubiquitous expression in bone marrow (RPKM 13.8), brain (RPKM 7.5) and 25 other tissues See more Orthologs mouse all

Preferred Names

signal transducing adapter molecule 1

Names

HSE1 homolog

signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Peptide sequence

https://www.ncbi.nlm.nih.gov/protein/NP_001311212.1

Related articles in PubMed

1. Backbone 1H, 13C, and 15N assignments for the tandem ubiquitin binding domains of signal transducing adapter molecule 1(STAM1). Lim J, et al. Biomol NMR Assign, 2011 Apr. PMID 20927613
2. Conformational and dynamic changes at the interface contribute to ligand binding by ubiquitin. Sundd M. Biochemistry, 2012 Oct 16. PMID 23035694
3. Solution structure of UIM and interaction of tandem ubiquitin binding domains in STAM1 with ubiquitin. Lim J, et al. Biochem Biophys Res Commun, 2011 Feb 4. PMID 21187078
4. Identification of a novel ubiquitin binding site of STAM1 VHS domain by NMR spectroscopy. Hong YH, et al. FEBS Lett, 2009 Jan 22. PMID 19111546
5. AMSH is an endosome-associated ubiquitin isopeptidase. McCullough J, et al. J Cell Biol, 2004 Aug 16. PMID 15314065, Free PMC Article
   

See all (78) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. The beta-arrestin1.STAM1 complex is necessary for promoting autophosphorylation of focal adhesion kinase (FAK). FAK is necessary for CXCL12-induced chemotaxis and associates with and localizes with beta-arrestin1 and STAM1 in a CXCL12-dependent manner.
2. The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains
3. Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes.
4. ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation.
5. Overexpression of an AIP4 catalytically inactive mutant and a mutant that shows poor binding to STAM-1 fails to enhance CXCR4-induced ERK-1/2 signaling.
6. Observational study of gene-disease association. (HuGE Navigator)
7. A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed.
8. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
9. The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM
10. Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element.
    

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