ESCRT-0, STAM2 (Kr.2q22.3), Hbp,STAM-2 (SH3-domeeni ja ITAM motiivi)

ESCRT_0, STAM2, (Kr.2.q23.3), Hbp, STAM2A, STAM2B

https://www.ncbi.nlm.nih.gov/gene/10254

Also known as Hbp; STAM2A; STAM2B

Summary The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation. [provided by RefSeq, Jul 2008]

Expression Ubiquitous expression in testis (RPKM 10.8), thyroid (RPKM 10.4) and 25 other tissues See more

Orthologs mouse all

Preferred Names

signal transducing adapter molecule 2

Names

HSE1 homolog

Hrs-binding protein

STAM-2

STAM-like protein containing SH3 and ITAM domains 2

signal transducing adaptor molecule (SH3 domain and ITAM motif) 2

Conserved Domains (4) summary

cd11963
Location:204 → 260

SH3_STAM2; Src homology 3 domain of Signal Transducing Adaptor Molecule 2

cd03568
Location:9 → 143

VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...

pfam02809
Location:166 → 181

UIM; Ubiquitin interaction motif

pfam03127
Location:296 → 367

GAT; GAT domain

Related articles in PubMed

1. Immunohistochemical expression of STAM2 in gastrointestinal stromal tumors. Džombeta T, et al. Anticancer Res, 2014 May. PMID 24778033
2. Evidence for cooperative and domain-specific binding of the signal transducing adaptor molecule 2 (STAM2) to Lys63-linked diubiquitin. Lange A, et al. J Biol Chem, 2012 May 25. PMID 22493438, Free PMC Article
3. Neurons and a subset of interstitial cells of Cajal in the enteric nervous system highly express Stam2 gene. Kapuralin K, et al. Anat Rec (Hoboken), 2012 Jan. PMID 22140097
4. Competitive binding of UBPY and ubiquitin to the STAM2 SH3 domain revealed by NMR. Lange A, et al. FEBS Lett, 2012 Sep 21. PMID 22841719
5. NMR reveals a different mode of binding of the Stam2 VHS domain to ubiquitin and diubiquitin. Lange A, et al. Biochemistry, 2011 Jan 11. PMID 21121635
   

See all (74) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.
2. The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains
3. homologous domain of human Bro1 domain-containing proteins, Alix and Brox, binds CHMP4B but not STAM2, despite their high structural similarity
4. correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors
5. The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements.
6. the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting
7. Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive.
8. report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins.
9. PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2
10. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex
    

Submit: New GeneRIF Correction See all GeneRIFs (12)