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måndag 21 maj 2018

ESCRT-0 vaiheesta kuva


https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172707_200302136f7&req=4

 ( Vps27 rekrytoi seuraavan kompleksi ESCRT-1).

 Model for compartment specification of Ub-dependent sorting into MVB vesicles. The Vps15/Vps34 complex synthesizes PI(3)P on endosomal membranes. The class E Vps protein Vps27 is targeted to PI(3)P- containing endosomal membranes via its FYVE domain (dark blue) where it can bind ubiquitinated MVB cargo via its UIM motifs (yellow). Vps27 subsequently recruits/activates ESCRT-I (orange) on endosomes. Ubiquitinated cargo (such as pCPS) is recognized by ESCRT-I (via the Ub E2 variant domain of Vps23), which initiates cargo entry into MVB vesicles. The action of a number of additional class E Vps proteins (ESCRT-II and ESCRT-III) is required for not only the function of this pathway but also for recruiting the deubiquitinating enzyme to remove Ub from cargo before its entry into invaginating vesicles. The concerted action of these proteins results in the sorting of cargo into the MVB pathway.


fig7: Model for compartment specification of Ub-dependent sorting into MVB vesicles. The Vps15/Vps34 complex synthesizes PI(3)P on endosomal membranes. The class E Vps protein Vps27 is targeted to PI(3)P- containing endosomal membranes via its FYVE domain (dark blue) where it can bind ubiquitinated MVB cargo via its UIM motifs (yellow). 
Vps27 subsequently recruits/activates ESCRT-I (orange) on endosomes. Ubiquitinated cargo (such as pCPS) is recognized by ESCRT-I (via the Ub E2 variant domain of Vps23), which initiates cargo entry into MVB vesicles. The action of a number of additional class E Vps proteins (ESCRT-II and ESCRT-III) is required for not only the function of this pathway but also for recruiting the deubiquitinating enzyme to remove Ub from cargo before its entry into invaginating vesicles. The concerted action of these proteins results in the sorting of cargo into the MVB pathway.  


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1648078/ 
Taulukon alkuosa ESCRT-0  ei ole  kovin helppoa hamottaa, sillä siihen  konvertoituu monenlaista tekijää, Olen nyt katosnut HRS geenin. Nyt katson  STAM geenit. 

Table 1

Class E Vps proteins and Complexes
ComplexYeast proteinHuman proteinMotifsBinds to
Vps27-Hse1 complexVps27HRSUIM, FYVE, VHSUbiquitin, PI(3)P, ESCRT-II (Vps23)

Hse1STAM1, STAM2UIM, VHS, SH3Ubiquitin
ESCRT-I complexVps23TSG101UEVUbiquitin, Vps27

Vps28VPS28


Vps37VPS37A, B, C, DCoiled-coil
ESCRT-II complexVps22EAP30Coiled-coil

Vps25EAP25
ESCRT-III (Vps20)

Vps36EAP45GLUE, NZFUbiquitin
ESCRT-III complexVps2/Did4CHMP2A, BCharged, Coiled-coil

Vps20CHMP6Charged, Coiled-coilESCRT-II (Vps25)

Vps24CHMP3Charged, Coiled-coil

Snf7/Vps32CHMP4A, B, CCharged, Coiled-coil
Vps4 complexVps4VPS4A, BAAA ATPase, Coiled-coilESCRT-III
Other MVB ProteinsBro1/Vps31ALIX/AIP1Charged, Coiled-coilLBPA, Doa4, ESCRT-III

Vps60/Mos10CHMP5Charged, Coiled-coilESCRT-III

Fti1/Did2CHMP1A, BCharged, Coiled-coilESCRT-III

Vta1LIP5
Vps4

Vps44/Nhx1SLC9A6Sodium/Proton Exchanger
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