TRIM35 (Kr.8p21.2) , HLS5, MAIR (C_IV, PRY SPRY) Hematopoieettisen linjan vaihdeproteiini

https://www.ncbi.nlm.nih.gov/gene/23087

TRIM35 geeni omaa muita nimiäkin: HLS5; MAIR.

HLS5 tarkoittaa Hematopoietic Lineage Switch protein 5

Kolmeosainen Trim motiivi sisältää kolme sinkkiä sitovaa domeenia RING, BBox1, BBox2 ja siten  coiled coil- domeenin.  C-terminaalissa on PRY SPRY, jotn tämän TRIMjäsenen  rakenne on alaluokkaa C_IV.  

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]

Yhden isoformin rakenteesta : 

https://www.ncbi.nlm.nih.gov/protein/NP_001291424.1 

Expression

Ubiquitous expression in skin (RPKM 5.7), testis (RPKM 5.1) and 25 other tissues See more

 

Uudempia viiteartikkeleita.

Related articles in PubMed

1. miR-4417 Targets Tripartite Motif-Containing 35 (TRIM35) and Regulates Pyruvate Kinase Muscle 2 (PKM2) Phosphorylation to Promote Proliferation and Suppress Apoptosis in Hepatocellular Carcinoma Cells. Song L, et al. Med Sci Monit, 2017 Apr 10. PMID 28394882, Free PMC Article
2. Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma. Chen Z, et al. Oncotarget, 2015 Feb 10. PMID 25576919
3. TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma. Chen Z, et al. Oncogene, 2015 Jul 23. PMID 25263439
4. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. Lalonde JP, et al. J Biol Chem, 2004 Feb 27. PMID 14662771
5. Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function. Kimura F, et al. J Biol Chem, 2003 Jul 4. PMID 12692137

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Authors subsequently investigated whether miR-4417 and TRIM35 regulate HCC cell proliferation and apoptosis through PKM2 Y105 phosphorylation, and the results supported our speculation that miR-4417 targets TRIM35 and regulates the Y105 phosphorylation of PKM2 to promote hepatocarcinogenesis.
2. Data suggest that pyruvate kinase isoform M2 (PKM2)/tripartite motif-containing 35 (TRIM35) expression could be a biomarker for the prognosis of hepatocellular carcinoma (HCC) and target for cancer therapy.
3. TRIM35 regulates the Warburg effect and tumorigenicity through interaction with PKM2 in hepatocellular carcinoma.
4. gene located on chromosome 8p21, a region implicated in leukemias and solid tumors; enforced expression inhibited cell growth, clonogenicity, and tumorigenicity; conceivable HLS5 is one of the tumor suppressor genes thought to reside at the 8p21 locus