TRIM36,(Kr.5q22.3), RBCC728, RNF98, HAPRIN,ANPH

 

TRIM36 (Kr.5q22),RBCC728, RNF98, HAPRIN

Alaryhmä CI (RING,B-Box2, C-C, COS,FN3,SPRY)

• https://www.nature.com/articles/s41419-017-0197-y"TRIM36, a novel androgen-responsive gene, enhances anti-androgen efficacy against prostate cancer by inhibiting MAPK/ERK signaling pathways"

PubMed Gene  "TRIM36". Tämä geeni on tunnettu myös nimillä RNF98, ANPH , HAPRIN ja RBCC728. Siitä pleissautuu useita transkriptivariantteja, jotka koodaavat eri proteiineja.  Tämä  geeni ilmenee  eniten testiksessä ja aivoissa. vain 4 muussa kudoksessa näiden lisäksi.

• Also known as

• ANPH; RNF98; HAPRIN; RBCC728
• Summary
• The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]Expression: Biased expression in testis (RPKM 36.6), brain (RPKM 4.1) and 4 other tissues See more

Mitä artikkeleita PubMed  ensisijaisesti esittää tästä geenistä?
TRIM36 omaa ubikitiiniligaasiaktiivisuutta ja tekee vuorovaikutuksen  sentromeeriseen CENP-H-proteiiniin , joka on kinetokoriproteeineja. Lisäksi se asettuu  samoihin kohtiin kuin alfatubuliini ( mikrotubulusproteiineja).
 Jos TRIM36-geeniä yli-ilmenee, se vaikuttaa solusyklin kiihtymisen alenemista ja  heikentää solun kasvua.Siis viivettöä solun proliferaatioon. 
Tällainen viittaisi siihen, että  liikamäärissä TRIM36 voisi aiheuttaa kromosomaalista instabiliteettiä.

Related articles in PubMed

1. ^{TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation}. He Z, et al. Environ Pollut, 2017 Jun. PMID 28359976
2. Identification of human HAPRIN potentially involved in the acrosome reaction. Kitamura K, et al. J Androl, 2005 Jul-Aug. PMID 15955891
3. Cloning and characterisation of the RBCC728/TRIM36 zinc-binding protein from the tumor suppressor gene region at chromosome 5q22.3. Balint I, et al. Gene, 2004 May 12. PMID 15145053
4. A homozygous mutation in TRIM36 causes autosomal recessive anencephaly in an Indian family. Singh N, et al. Hum Mol Genet, 2017 Mar 15. PMID 28087737
5. TRIM36 interacts with the kinetochore protein CENP-H and delays cell cycle progression. Miyajima N, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232519Abstract
   The tripartite motif-containing protein (TRIM) family is defined by the presence of a common domain structure composed of a RING finger, a B-box, and a coiled-coil motif. TRIM family proteins are involved in a broad range of biological processes and, consistently, their alterations result in diverse pathological conditions such as genetic diseases, viral infection, and cancer development. In this study, we found by using yeast two-hybrid screening that TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, one of the kinetochore proteins. We also found by immunofluorescence analysis that TRIM36 colocalizes with alpha-tubulin, one of the microtubule proteins. Moreover, we found that overexpression of TRIM36 decelerates the cell cycle and attenuates cell growth. These results indicate that TRIM36 is potentially associated with chromosome segregation and that an excess of TRIM36 may cause chromosomal instability.
   
    https://www.google.se/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=2ahUKEwjru5Hx-pvaAhUFVSwKHQsuDQwQjRx6BAgAEAU&url=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FThe-centromere-kinetochore-regionAt-the-heart-of-the-kinetochore-is-a-specialized_fig2_51390853&psig=AOvVaw3guLBSBtGH_LK4reZSgEfc&ust=1522771099669847

See all (17) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure
2. The siRNA knock down of TRIM36 in HeLa and LN229 cells also led to reduced cell proliferation and increased apoptosis. We suggest that microtubule disruption and disorganized spindles mediated by mutant TRIM36 affect neural cell proliferation during neural tube formation, leading to Anencephaly .
3. TRIM36 is the causative gene for autosomal recessive anencephaly
4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
5. TRIM36 has a ubiquitin ligase activity and interacts with centromere protein-H, potentially associated with chromosome segregation and its excess may cause chromosomal instability.
6. The overexpression of the TRIM36 in the vast majority of prostate cancer suggest that this gene might be involved in the prostate tumorigenesis.
7. molecular cloning and characterization of a human haprin ortholog