TRIM29 (Kr.11q23.3) muita funktioita , STING degradaatio

 TRIM29 ja  sen  negatiivisen säädön kohdemolekyyli  STING

Kts. Kartta STING sijainnista  TRIM kartalla (kartan vasen alakulma)

 http://www.mdpi.com/2076-393X/5/3/23/htm

Sytosolinen DNA (DNA virus ja dsDNA) saavat TRIM29 indusoimaan luonnollisen immuunivasteen negatiivisen kontrollin vähentämällä STING_TBK1-IRF3  signalointia

Select item 295818861. TRIM29 negatively controls antiviral immune response through targeting STING for degradation.Li Q, Lin L, Tong Y, Liu Y, Mou J, Wang X, Wang X, Gong Y, Zhao Y, Liu Y, Zhong B, Dai L, We YQ, Zhang H, Hu H. Cell Discov. 2018 Mar 20;4:13. doi: 10.1038/s41421-018-0010-9. eCollection 2018.PMID: 29581886 Free PMC Article Similar articles (Suomennosta) TRIM29 ubikitiini E3 ligaasi toimii indusoivana negatiivisena säätelijänä luonnollisessa immuniteetissa DNA-viruksen ja sytosolissa olevan DNA:n stimuloimana. DNA-virus ja sytosolinen DNA indusoivat runsaan TRIM29 ilmenemän makrofageissa ja dendriittisoluissa (DC)vaikka noissa soluissa basaalia TRIM29 ei ole havaittaavissa. TRIM29 -puute aiheuttaa virusDNA:sta ja sytosolisesta dsDNA:sta johtuvan IFN-1 ja proinflammatoristen sytokiinien pitoisuuden nousun. Johdonmukaisesti niden tietojen kanssa in vivo-kokeissa osoitetaan, että TRIM29 vajeiset hiiret ovat resistentimpiä HSV-1 herpesvirusta kohtaan kuin wt kontrollihiiret ja tähän viitaavat parempi elossapysymisfrekvenssi ja elinten alempi viruskuorma. Mekanistiset tutkimukset osoittavat, että STING-TBK1-IRF3-signaalitie TRIM29 poistogeenisissä soluissa on merkitsevästi lisääntynyt, ja STING-proteiinin hajoaminen taas huonontunut. Normaali TRIM29 kohdentuu STING-proteiiniin johtaen sen K48 ubikitinaatioon ja hajoamaan. Tämä tutkimus osoitaa TRIM29:n olevan ratkaiseva negatiivinen säätelijä DNA virusta ja sytosolista dsDNA:ta vastaan muodostuneessa immuunivasteessa tarkoituksena estää ylisuurista immuunivasteista kertyvä vaur mahdollinen vaurio.

• Here we report TRIM29, a ubiquitin E3 ligase, functions as an inducible negative regulator of innate immune response triggered by DNA virus and cytosolic DNA. DNA virus and cytosolic DNA stimulation induce TRIM29 expression robustly in macrophages and dendritic cells, although the basal level of TRIM29 is undetectable in those cells. TRIM29 deficiency elevates IFN-I and proinflammatory cytokine production upon viral DNA and cytosolic dsDNA stimulation. Consistently, in vivo experiments show that TRIM29-deficient mice are more resistant to HSV-1 infection than WT controls, indicated by better survival rate and reduced viral load in organs. Mechanism studies suggest that STING-TBK1-IRF3 signaling pathway in TRIM29 KO cells is significantly enhanced and the degradation of STING is impaired. Furthermore, we identify that TRIM29 targets STING for K48 ubiquitination and degradation. This study reveals TRIM29 as a crucial negative regulator in immune response to DNA virus and cytosolic DNA, preventing potential damage caused by overcommitted immune responses.

TRIM29 promotes DNA virus infections by inhibiting innate immune response. Xing J, Zhang A, Zhang H, Wang J, Li XC, Zeng MS, Zhang Z. Nat Commun. 2017 Oct 16;8(1):945. doi: 10.1038/s41467-017-00101-w.PMID: 29038422 Free PMC Article Similar articles
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TRIM29 on monissa syövissä prognostinen merkitsijä

Select item 295523133.
TRIM29 as a prognostic predictor for multiple human malignant neoplasms: a systematic review and meta-analysis.Liang C, Dong H, Miao C, Zhu J, Wang J, Li P, Li J, Wang Z.Oncotarget. 2017 Dec 22;9(15):12323-12332. doi: 10.18632/oncotarget.23617. eCollection 2018 Feb 23. PMID: 29552313 Free PMC Article Similar articles

Select item 295563082.
Prognostic value of tripartite motif containing 29 expression in patients with gastric cancer following surgical resection.Wang C, Zhou Y, Chen B, Yuan W, Huang J.Oncol Lett. 2018 Apr;15(4):5792-5798. doi: 10.3892/ol.2018.8059. Epub 2018 Feb 15.PMID: 29556308 Free PMC ArticleSimilar articles

TRIM 29 ja EMT

Select item 292286924.
Epigenetic landscape change analysis during human EMT sheds light on a key EMT mediator TRIM29. Choi SK, Pandiyan K, Eun JW, Yang X, Hong SH, Nam SW, Jones PA, Liang G, You JS. Oncotarget. 2017 Oct 9;8(58):98322-98335. doi: 10.18632/oncotarget.21681. eCollection 2017 Nov 17.PMID: 29228692 Free PMC Article Similar articles
Select item 290384225.

Select item 287311677.
High expression of TRIM29 (ATDC) contributes to poor prognosis and tumor metastasis by inducing epithelial‑mesenchymal transition in osteosarcoma. Zeng SX, Cai QC, Guo CH, Zhi LQ, Dai X, Zhang DF, Ma W. Oncol Rep. 2017 Sep;38(3):1645-1654. doi: 10.3892/or.2017.5842. Epub 2017 Jul 21.PMID: 28731167 Similar articles

Select item 2818608910.
Adenovirus-mediated TIPE2 overexpression inhibits gastric cancer metastasis via reversal of epithelial-mesenchymal transition.Yin H, Huang X, Tao M, Hu Q, Qiu J, Chen W, Wu J, Xie Y.Cancer Gene Ther. 2017 Apr;24(4):180-188. doi: 10.1038/cgt.2017.3. Epub 2017 Feb 10.PMID: 28186089 Similar articles

TRIM29(ATCD):  havaittu ei-klassinen  osallistuja  Wnt/beta-cateniini signaloinnissa   ( ei mitenkään  yksinkertainen asia)

https://www.medscape.com/viewarticle/734129_5

Diallyl trisulfide inhibits proliferation, invasion and angiogenesis of glioma cells by inactivating Wnt/β-catenin signaling. Tao Q, Wu C, Xu R, Niu L, Qin J, Liu N, Zhang P, Wang C. Cell Tissue Res. 2017 Dec;370(3):379-390. doi: 10.1007/s00441-017-2678-9. Epub 2017 Aug 17.PMID: 28815294 Similar articles
 
Select item 286783278.
LncRNA625 modulates prostate cancer cells proliferation and apoptosis through regulating the Wnt/β-catenin pathway by targeting miR-432. Li JB, Liu F, Zhang BP, Bai WK, Cheng W, Zhang YH, Yu LJ.Eur Rev Med Pharmacol Sci. 2017 Jun;21(11):2586-2595. PMID: 28678327 Free Article Similar articles
 
Select item 282164179.
Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers.Panaccione A, Guo Y, Yarbrough WG, Ivanov SV.Clin Breast Cancer. 2017 Jul;17(4):298-306.e7. doi: 10.1016/j.clbc.2017.01.007. Epub 2017 Jan 27.PMID: 28216417 Similar articles
 

TRIM29 ja  PI3K/AKT signalointi  tyreoideakarsinoomassa

Select item 2809887211.
TRIM29 promotes progression of thyroid carcinoma via activating P13K/AKT signaling pathway.
Xu J, Li Z, Su Q, Zhao J, Ma J.Oncol Rep. 2017 Mar;37(3):1555-1564. doi: 10.3892/or.2017.5364. Epub 2017 Jan 13.PMID: 28098872 Similar articles
 
Select item 2805430212.
microRNA-761 induces aggressive phenotypes in triple-negative breast cancer cells by repressing TRIM29 expression.Guo GC, Wang JX, Han ML, Zhang LP, Li L.Cell Oncol (Dordr). 2017 Apr;40(2):157-166. doi: 10.1007/s13402-016-0312-6. Epub 2017 Jan 4.PMID: 28054302 Similar articles
 

 TRIM29 ja hengitystiealue

Select item 2784919714.
Corrigendum: Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.Xing J, Weng L, Yuan B, Wang Z, Jia L, Jin R, Lu H, Li XC, Liu YJ, Zhang Z.Nat Immunol. 2016 Nov 16;17(12):1479. doi: 10.1038/ni1216-1479a. No abstract available. PMID: 27849197 Similar articles
 
Select item 2769500115.
Identification of a role for TRIM29 in the control of innate immunity in the respiratory tract.Xing J, Weng L, Yuan B, Wang Z, Jia L, Jin R, Lu H, Li XC, Liu YJ, Zhang Z.Nat Immunol. 2016 Dec;17(12):1373-1380. doi: 10.1038/ni.3580. Epub 2016 Oct 3. Erratum in: Nat Immunol. 2016 Nov 16;17 (12 ):1479. PMID: 27695001 Free PMC Article Similar articles
 
Select item 2698739116.
TRIM29 Overexpression Promotes Proliferation and Survival of Bladder Cancer Cells through NF-κB Signaling.Tan ST, Liu SY, Wu B.Cancer Res Treat. 2016 Oct;48(4):1302-1312. Epub 2016 Mar 11. PMID: 26987391 Free PMC Article Similar articles
 

 TRIM29 säätyy ylös hypoxiastressistä ATM/HIFIa riippuvasti ja on  onkogeenin TWIST1 antagonisti.

Select item 2753522417.
The Breast Cancer Tumor Suppressor TRIM29 Is Expressed via ATM-dependent Signaling in Response to Hypoxia. Dükel M, Streitfeld WS, Tang TC, Backman LR, Ai L, May WS, Brown KD.J Biol Chem. 2016 Oct 7;291(41):21541-21552. Epub 2016 Aug 17. PMID: 27535224 Free PMC ArticleSimilar articles
Reduced ATM function has been linked to breast cancer risk, and the TRIM29 protein is an emerging breast cancer tumor suppressor. Here we show that, in cultured breast tumor and non-tumorigenic mammary epithelial cells, TRIM29 is up-regulated in response to hypoxic stress but not DNA damage. Hypoxia-induced up-regulation of TRIM29 is dependent upon ATM and HIF1α and occurs through increased transcription of the TRIM29 gene. Basal expression of TRIM29 is also down-regulated in cells expressing diminished levels of ATM, and findings suggest that this occurs through basal NF-κB activity as knockdown of the NF-κB subunit RelA suppresses TRIM29 abundance. We have previously shown that the activity of the TWIST1 oncogene is antagonized by TRIM29 and now show that TRIM29 is necessary to block the up-regulation of TWIST1 that occurs in response to hypoxic stress. This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression.

 TRIM29 onkogeeninen vaikutus JAK2/STAT3 signalointitietä

Select item 2743034518.
RNA interference against TRIM29 inhibits migration and invasion of colorectal cancer cells.Xu W, Xu B, Yao Y, Yu X, Cao H, Zhang J, Liu J, Sheng H. Oncol Rep. 2016 Sep;36(3):1411-8. doi: 10.3892/or.2016.4941. Epub 2016 Jul 15.PMID: 27430345 Similar articles
 TRIM29 may exert oncogenic effects in CRC cells via regulating JAK2/STAT3 signaling.
 

TRIM29 metastaasin merkitsijä  nasofaryngeaalisyövässä

Select item 2714537420.
Identification of nasopharyngeal carcinoma metastasis-related biomarkers by iTRAQ combined with 2D-LC-MS/MS. Chen Z, Long L, Wang K, Cui F, Zhu L, Tao Y, Wu Q, Xiang M, Liang Y, Qiu S, Xiao Z, Yi B.Oncotarget. 2016 Jun 7;7(23):34022-37. doi: 10.18632/oncotarget.9067. PMID: 27145374 Free PMC ArticleSimilar articles