https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-8-8
Figure 1
Activation of the G2/M checkpoint after DNA damage.
In response to DNA damage, the ATM, ATR signaling pathway is activated,
which leads to the phosphorylation and activation of Chk1 and Chk2 and
to the subsequent phosphorylation of Cdc25. Phosphorylated Cdc25 is
sequestered in the cytoplasm by 14-3-3 proteins, which prevents
activation of cyclinB/Cdk1 by Cdc25 and results in G2 arrest. Activated
ATM/ATR also activates p53-dependent signaling. This contributes to the
maintenance of G2 arrest by upregulating 14-3-3, which sequesters Cdk1
in the cytoplasm. In addition, p53 induces the transactivation of p21, a
Cdk inhibitor that binds to and inhibits cyclinB/Cdk1 complexes. P:
phosphorylation.
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