TRIM21 (Kr.11p15.4) RNF81,Sicca Syndrome Antigen 1, RoSSA, Ribonucleoprotein autoantigen SS_A

TRIM21 (Kr.11p15.4), RNF81, (C_IV, PRYSPRY), Sicca Syndrome_Antigen A , RoSSA, Ribonucleoprotein autoantigen SS_A, Sjögren Syndrome antigen A1, 52kDa Ro protein

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2329685/

TRIM 21 geenillä on konservatiiviset domeenit RING, BBox1, Bbox2 ja Coiled coil. C-terminaali on PRYS/SPRY, joten se on C-IV- alaluokkaa. Koodautunut proteiini on osana RoSSA ribonukleoproteiinia, joka käsittää yksittäisen polypeptidin ja neljä pientä RNA molekyyiä. RoSSA-partikkeli lokalisoituu sekä sytoplasmaan että tmaan. RoSSA tekee interaktioita autoantigeenien kanssa esim Sjögrenin syndromapotilailla ja SLE-potilalla. Vaihtoehtoisesti pleissautuneita variantteja on kuvattu, mutta täyspitkää vain yksi. Geeniä ilmenee eniten pernassa, umpilisäkkeessä, sitten keuhkoissa ja imusolmukkeissa ja 22 muussa kudoksessa. (Suomennos kesken)

• SSA; RO52; SSA1; RNF81; Ro/SSA Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in spleen (RPKM 15.5), appendix (RPKM 13.2) and 24 other tissues See more Orthologs mouse all
• Names: Preferred Names

E3 ubiquitin-protein ligase TRIM21

Names

52 kDa Ro protein

52 kDa ribonucleoprotein autoantigen Ro/SS-A

RING finger protein 81

RING-type E3 ubiquitin transferase TRIM21

SS-A

Sicca syndrome antigen A

Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)

ro(SS-A)

sjoegren syndrome type A antigen

tripartite motif-containing protein 21

NP_003132.2

• EC 2.3.2.27

• Conservative domains

smart00336
Location:91 → 128

BBOX; B-Box-type zinc finger

cd12900
Location:287 → 465

SPRY_PRY_TRIM21; PRY/SPRY domain in tripartite motif-binding protein 21 (TRIM21) also known as 52kD Ribonucleoprotein Autoantigen (Ro52)

cd16596
Location:12 → 55

RING-HC_TRIM21_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein TRIM21 and similar proteins

cl25732
Location:67 → 238

SMC_N; RecF/RecN/SMC N terminal domain

Related articles in PubMed

1. Ro60/SSA levels are increased and promote the progression of pancreatic ductal adenocarcinoma. Liu D, et al. Biochem Biophys Res Commun, 2018 Jan 22. PMID 29274781
2. Ro52/TRIM21-deficient expression and function in different subsets of peripheral blood mononuclear cells is associated with a proinflammatory cytokine response in patients with idiopathic inflammatory myopathies. Gómez-Martín D, et al. Clin Exp Immunol, 2017 Apr. PMID 27936488, Free PMC Article
3. Alterations of TRIM21-mRNA expression during monocyte maturation. Lenart M, et al. Immunobiology, 2017 Mar. PMID 27773663
4. Monospecific anti-Ro52/TRIM21 antibodies in a tri-nation cohort of 1574 systemic sclerosis subjects: evidence of an association with interstitial lung disease and worse survival. Wodkowski M, et al. Clin Exp Rheumatol, 2015 Jul-Aug. PMID 26315678
5. Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Fletcher AJ, et al. Proc Natl Acad Sci U S A, 2015 Aug 11. PMID 26150489, Free PMC Article
   

See all (146) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Taken together, the current study provides evidence of new function of Ro60/SSA in the development of cancer. It facilitates pancreatic cancer proliferation, migration and invasion. Therefore, it may represent a novel molecular target for the management of pancreatic cancer.
2. We suggest that TRIM21 may be one of the factors associated with the "switching on" the proinflammatory programme in CD16(+) monocytes or monocyte-derived macrophages.
3. Authors demonstrate that TRIM21 expression predicts survival in pancreatic cancer patients. This work highlights a novel mechanism of Par-4 regulation, and identifies a novel prognostic marker and potential therapeutic target for pancreatic cancer.
4. TRIM21 role in TRAIL-induced apoptosis
5. Our data suggest that patients with IIM, mainly DM, are characterized by a deficient expression of Ro52/TRIM21 in different PBMC subsets (CD4(+) lymphocytes and monocytes), along with lower K48-mediated ubiquitination, which is associated with a proinflammatory cytokine response.
6. Significant relationships were found between clinical and laboratory manifestations of autoimmune and rheumatic diseases with different patterns of antibodies to anti-Ro52, anti-Ro60 and anti-La .
7. downregulation of miR-1207-5p and miR-4695-3p expression may lead to increased TRIM21 levels in the minor salivary glands, which contributes to the development of Sjogren's syndrome
8. The interaction of TRIM21 and LFG was analyzed by co-immunoprecipitation. To examine changes in regulatory processes, western blot analyses, real-time PCR, activity of apoptotic process and flow cytometric analyses were carried out.
9. TRIM21 plays an essential role in p62-regulated redox homeostasis and may be a viable target for treating pathological conditions resulting from oxidative damage.
10. TRIM21-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I
    

Submit: New GeneRIF Correction See all GeneRIFs (71)

Japanese Encephalitis virus and TRIM21

https://link.springer.com/article/10.1186/1742-2094-11-24

Muistiin 13.4. 2018, Suomennos kesken.