https://www.sciencedirect.com/science/article/pii/S0042682215000793#f0005
Löysin tällaisen tärkeän yleiskatsausksen polyubikitinaatioista ja otin tähä talteen kunnes olen tämän lukenut ja tehnyt muistiinpanoja.
Polyubikitinaation erilaisilla linkkiytymistyypeillä on funktionaaliset tehtävänsä. Alla olevassa kuvassa on esitety 8 erilaista polyubikitinaatiotyyppiä. Tekstissä selvitetään modifioitujen substraatien tunnettuja kohtaloita ja päätiet, joita spesifisin polyubikitinaatioin säädellään. Muualla tekstissä selvitetään erityisiä yksityiskohtia siitä, miten eri ubikitiinipolymeerit säätelevät substraattiproteiineja.
Fi
g. 1. Functional roles of
the different linkage types of polyubiquitination. The 8 different
linkage types of polyubiquitination are illustrated. Known fates of
modified substrates as well as key pathways regulated by specific
polyubiquitins are shown. The specific details of how different
ubiquitin polymers regulate substrate proteins are described in the
text.
Review
Ubiquitination in the antiviral immune response
Highlights
- •
Different linkage types of polyubiquitination regulate PRR signal transduction.
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K63-linked ubiquitination plays an important role in promoting RIG-I signaling.
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K48- and K63-linked ubiquitination fine-tunes TLR-dependent signal transduction.
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Cytosolic DNA sensing is regulated through ubiquitination of STING.
Abstract
Ubiquitination
has long been known to regulate fundamental cellular processes through
the induction of proteasomal degradation of target proteins. More
recently, ‘atypical’ non-degradative types of polyubiquitin chains have
been appreciated as important regulatory moieties by modulating the
activity or subcellular localization of key signaling proteins.
Intriguingly, many of these non-degradative types of ubiquitination
regulate the innate sensing pathways initiated by pattern recognition
receptors (PRRs), ultimately coordinating an effective antiviral immune
response. Here we discuss recent advances in understanding the
functional roles of degradative and atypical types of ubiquitination in
innate immunity to viral infections, with a specific focus on the
signaling pathways triggered by RIG-I-like receptors, Toll-like
receptors, and the intracellular viral DNA sensor cGAS.
Keywords
Antiviral immunity
Type-I interferon
RIG-I-like receptors
Toll-like receptors
cGAS
STING
Ubiquitin
E3 ligases
TRIM proteins
TRIM25
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