MUC14 (4q24) EMCN Endomusiini

https://www.ncbi.nlm.nih.gov/gene/51705

Also known as

EMCN2; MUC14

Summary

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes (FAC)  and inhibits interaction between cells and the extracellular matrix (ECM)  (Kinoshita et al., 2001 [PubMed 11418125]).[supplied by OMIM, Mar 2008]

Expression

Broad expression in kidney (RPKM 11.5), lung (RPKM 11.1) and 19 other tissues See more

Orthologs  mouse all

Protein: Preferred Names

endomucin

Names

MUC-14

endomucin-2

gastric cancer antigen Ga34

mucin-14

 https://www.ncbi.nlm.nih.gov/protein/NP_001153166.1

1. Association of EMCN with susceptibility to rheumatoid arthritis in a Japanese population. Nishimoto K, et al. J Rheumatol, 2011 Feb. PMID 21159824
2. Identification of tumour antigens by serological analysis of cDNA expression cloning. Li G, et al. Cancer Immunol Immunother, 2004 Mar. PMID 14722670
3. Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin. Kuhn A, et al. J Invest Dermatol, 2002 Dec. PMID 12485444
4. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. Samulowitz U, et al. Am J Pathol, 2002 May. PMID 12000719, Free PMC Article
5. Human endomucin is an endothelial marker. Liu C, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594763

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

 GeneRif

1. In contrast, endomucin (EMCN) is present on the lymphatic sinus endothelium and not on lymphatic endothelium of the subcapsular sinus. Moreover, both murine and human MSR1 on lymphatic endothelium of the SS bind lymphocytes and in in vivo studies MSR1 regulates entrance of lymphocytes from the SS to the lymph node parenchyma
2. These results indicate that endomucin prevents leukocyte contact with adhesion molecules in non-inflamed tissues and that downregulation of endomucin is critical to facilitate adhesion of leukocytes into inflamed tissues.
3. Knockdown of endomucin markedly attenuated endothelial cell growth, migration and tube formation.
4. A significant association between EMCN and rheumatoid arthritis susceptibility was detected in our Japanese study population. The EMCN allele conferring rheumatoid arthritis susceptibility may also contribute to the pathogenesis of rheumatoid arthritis.
5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)