MUC6 (11p15.5)
(Suomennosta) Tämä
geeni tunnetaan kahdella nimellä: MUC6 tai MUC-6. Geeni koodaa
musiinia, joka erittyy ja muoodstaa läpäisemätöntä
puolustusestettä, joka suojaa suolen ontelon pintaa. Geeniä ilmenee
mahalaukussa ja pohjukaissuolessa. Proteiinin nimen on musiini-6.
- Also known as MUC-6
- Summary This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016] Expression Biased expression in stomach (RPKM 174.6) and duodenum (RPKM 41.3) See more Orthologs mouse all Preferred Names mucin-6. Names gastric mucin-6
Artikkeleita
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Association of MUC6-minisatellite variants with susceptibility to rectal carcinoma. Ahn MH, et al. Mol Biol Rep, 2013 Jan. PMID 23054008
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MUC6 mucin expression inhibits tumor cell invasion. Leir SH, et al. Exp Cell Res, 2011 Oct 15. PMID 21851820
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MUC expression in hyperplastic and serrated colonic polyps: lack of specificity of MUC6. Gibson JA, et al. Am J Surg Pathol, 2011 May. PMID 21490447
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Tn
glycosylation of the MUC6 protein modulates its immunogenicity and
promotes the induction of Th17-biased T cell responses. Freire
T, et al. J Biol Chem, 2011 Mar 11. PMID 21193402, Free
PMC Article
Gene rif
- NM_005961.2 → NP_005952.2 mucin-6 precursor
- See
identical proteins and their annotated locations for NP_005952.2
- (Finnish) Konservoituja domeeneja ovat
- BDLF3 (https://www.mybiosource.com/prods/Recombinant-Protein/Probable-membrane-antigen-GP85-BDLF3/BDLF3/datasheet.php?products_id=7062925)
-
- Conserved Domains (8) summary
- PHA03255
Location:2188 → 2343- PHA03255; BDLF3; Provisional
- smart00041
Location:2351 → 2434- CT; C-terminal cystine knot-like domain (CTCK)
- smart00215
Location:359 → 403- VWC_out; von Willebrand factor (vWF) type C domain
- smart00216
Location:386 → 549- VWD; von Willebrand factor (vWF) type D domain
- pfam00094
Location:868 → 1017- VWD; von Willebrand factor type D domain
- pfam01826
Location:302 → 357- TIL; Trypsin Inhibitor like cysteine rich domain
- pfam08742
Location:1057 → 1127- C8; C8 domain
- cl17735
Location:829 → 886- VWC; von Willebrand factor type C domain
(Finnish) Historiallisia vaiheita.
- mucin-6 precursor [Homo sapiens]
LOCUS NP_005952 2439 aa linear PRI 19-AUG-2018 DEFINITION mucin-6 precursor [Homo sapiens].
(Finnish) 2018 Referenssi 1. Helikobacter pylori- virulenssitekijän Cag
A ja ammoniumjonin vaikutus musiineihin AGS-soluissa: vaikutusta on myös MUC6 ilmenemään.
-
REFERENCE 1 (residues 1 to 2439)
AUTHORS Zhang X, Shi D, Liu YP, Chen WJ and Wu D.
TITLE Effects of the Helicobacter pylori Virulence Factor CagA and
Ammonium Ion on Mucins in AGS Cells
JOURNAL Yonsei Med. J. 59 (5), 633-642 (2018)
PUBMED 29869461
REMARK GeneRIF: The expression of MUC5AC, MUC2, and MUC6 mRNA in
CagA-transfected AGS cells at an NH concentration of 15 mM was
significantly higher than that at 0 mM, and decreased at higher
concentrations. H. pylori may affect the expression of MUC5AC,
MUC2, MUC5B, and MUC6 in AGS cells via CagA and/or NH, but not
E-cadherin.
(Finnish) 2018 referenssi 2. immunohitokemialliset musiiniantigeenikirjot
sylkirauhasen mukoepidermaalisessa karsinoomassa.
Varhaisessa postoperatiivisessa vaiheessa MUC4- ja MUC6 –
negatiiviset ilmenemät ovat huonon ennusteen merkkejä.
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REFERENCE 2 (residues 1 to 2439)
AUTHORS Honjo K, Hiraki T, Higashi M, Noguchi H, Nomoto M, Yoshimura T,
Batra SK, Yonezawa S, Semba I, Nakamura N, Tanimoto A and Yamada S.
TITLE Immunohistochemical expression profiles of mucin antigens in
salivary gland mucoepidermoid carcinoma: MUC4- and MUC6-negative
expression predicts a shortened survival in the early postoperative
phase
JOURNAL Histol. Histopathol. 33 (2), 201-213 (2018)
PUBMED 28649694
REMARK GeneRIF: The detection of MUC4 and/or MUC6 might be a powerful
parameter in the clinical management of mucoepidermoid carcinoma in
the early postsurgical phase
(Finnish) 2017 referenssi 3.
Maharauhasen musiinispesifinen O-glykaani-ilmenemä alenee
tuumorin progredioituessa prekursorileesioista haimasyöväksi.
MUC6:een korreloivan alfaGlcNAc ilmenemän aleneminen tapahtuu
varhain ja merkitsee haimasyövän progredioitumisen alkamista.
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REFERENCE 3 (residues 1 to 2439)
AUTHORS Ohya A, Yamanoi K, Shimojo H, Fujii C and Nakayama J.
TITLE Gastric gland mucin-specific O-glycan expression decreases with
tumor progression from precursor lesions to pancreatic cancer
JOURNAL Cancer Sci. 108 (9), 1897-1902 (2017)
PUBMED 28685935
REMARK GeneRIF: decreased expression of alphaGlcNAc relative to MUC6
occurs early and marks the initiation of tumor progression to
pancreatic cancer.
(Finnish) 2016 Referenssi 4.
Musiinigeenien MUC1, MUC2, MUC5AX ja MUC6 ilmenemisprofiilit ja
kliininen merkitys kolorektaalissa syövässä. MUC5AC geenin ja
erityisesti MUC6 geenin poikkeava ilmentymä assosioitui
suotuisiin tuloksiin kolorektaalisyövässä intermediäärisissä
vaiheissa II ja III.
-
REFERENCE 4 (residues 1 to 2439)
AUTHORS Betge J, Schneider NI, Harbaum L, Pollheimer MJ, Lindtner RA,
Kornprat P, Ebert MP and Langner C.
TITLE MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression
profiles and clinical significance
JOURNAL Virchows Arch. 469 (3), 255-265 (2016)
PUBMED 27298226
REMARK GeneRIF: outcome, while the gain of aberrant expression of MUC5AC
and particularly of MUC6 was associated with favorable outcome in
colorectal cancer, notably in intermediate stages II and III’
(Finnish) 2015 referenssi 5. Musiinien MUC1, MUC2, MUC5AC ja MUC6
ilmenemisprofiili ovariaalisessa musinoosissa tuumorissa:
Ilmenemän muutokset benigneistä rajatilaan ja maligneihin tuumoreihin.
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REFERENCE 5 (residues 1 to 2439)
AUTHORS Wang J and El-Bahrawy M.
TITLE Expression profile of mucins (MUC1, MUC2, MUC5AC, and MUC6) in
ovarian mucinous tumours: changes in expression from benign to
malignant tumours
JOURNAL Histopathology 66 (4), 529-535 (2015)
PUBMED 25298197
REMARK GeneRIF: In ovarian mucinous tumors, MUC6 expression changes with
the progression of benign to borderline and malignant tumours
(Finnish) 2004 referenssi 6. Ihmisen MUC6 ja MUC2 geenien täydellinen
genominen järjestäytyminen. Täydellinen exoni/introni-organisoituminen.
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REFERENCE 6 (residues 1 to 2439)
AUTHORS Rousseau K, Byrne C, Kim YS, Gum JR, Swallow DM and Toribara NW.
TITLE The complete genomic organization of the human MUC6 and MUC2 mucin
genes.
JOURNAL Genomics 83 (5), 936-939 (2004)
PUBMED 15081123
REMARK GeneRIF: complete genomic (exon/intron) organization
(Finnish) 1998 referenssi 7. MUC6 musiinigeeniä ilmenee
epiteelikudoksissa laajalla variaatiolla.
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REFERENCE 7 (residues 1 to 2439)
AUTHORS Bartman AE, Buisine MP, Aubert JP, Niehans GA, Toribara NW, Kim YS,
Kelly EJ, Crabtree JE and Ho SB.
TITLE MUC6 secretory mucin gene is expressed in a wide variety of
epithelial tissues
JOURNAL J. Pathol. 186 (4), 398-405 (1998)
PUBMED 10209489
(Finnish) 1998 Referenss 8. Ihmisen musiinigeenit MUC2, MUC3, MUC4,
MUS5AC ja MUC6 ilmentyvät vakaasti ja niillä on erittäin laaja mRNA
ja niissä ilmenee vaihtelevaa pituuspolymorfiaa. On eräs parannettu
tutkimusmetodi laajojen mRNA- sekvenssien analysoimiseen.
-
REFERENCE 8 (residues 1 to 2439)
AUTHORS Debailleul V, Laine A, Huet G, Mathon P, d'Hooghe MC, Aubert JP and
Porchet N.
TITLE Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express
stable and extremely large mRNAs and exhibit a variable length
polymorphism. An improved method to analyze large mRNAs
JOURNAL J. Biol. Chem. 273 (2), 881-890 (1998)
PUBMED 9422745
(Finnish) 1997 Referenssi 9. On analysoitu MUC6 -sekretorisen musiinin
C-terminaali ja primaarinen aminohappojärjestys
-
REFERENCE 9 (residues 1 to 2439).
AUTHORS Toribara NW, Ho SB, Gum E, Gum JR Jr, Lau P and Kim YS.
TITLE The carboxyl-terminal sequence of the human secretory mucin, MUC6.
Analysis Of the primary amino acid sequence
JOURNAL J. Biol. Chem. 272 (26), 16398-16403 (1997)
PUBMED 9195947
(Finnish) 1993 referenssi 10. Ihmisen gastrinen mukoosi.
Ilmenemän kloonauksessa on tunnistettu eräs ainutlaatuinen laji.
REFERENCE 10 (residues 1 to 2439)
AUTHORS Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR
Jr, Byrd JC, Siddiki B and Kim YS.
TITLE Human gastric mucin. Identification of a unique species by
expression cloning
JOURNAL J. Biol. Chem. 268 (8), 5879-5885 (1993)
PUBMED 7680650
(Finnish) Kommentti 2007
Sekvenssin päivitys on tehty 25.7.2007.
Aminohappoja 1..2439 ”mucin-6-prekursori”
1..22
23.. 2439 tuote ”Mucin-6”
Domeeneja:
VWD,C8,TIL,VWC,VWD,C8,TIL,TIL,VWC,VWD,C8,Trunc,Appr.repeats,BDLF3,CT.
-
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC139749.4. This sequence is a reference standard in the RefSeqGene project. On or before Jul 25, 2007 this sequence version replaced XP_290540.7, XP_949181.2, NP_005952.1. Summary: This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016]. Sequence Note: The RefSeq transcript was derived from genomic sequence based on transcript alignments and the published description of the gene structure (PubMed ID 15081123). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..2439 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="11" /map="11p15.5" Protein 1..2439 /product="mucin-6 precursor" /note="mucin-6; gastric mucin-6" /calculated_mol_wt=254750 sig_peptide 1..22 /experiment="experimental evidence, no additional details recorded" /note="{ECO:0000255}; propagated from UniProtKB/Swiss-Prot (Q6W4X9.3)" /calculated_mol_wt=2321 mat_peptide 23..2439 /product="Mucin-6" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q6W4X9.3)" /calculated_mol_wt=254750 Region 40..192 /region_name="VWD" /note="von Willebrand factor (vWF) type D domain; smart00216" /db_xref="CDD:214566" Region 228..297 /region_name="C8" /note="C8 domain; pfam08742" /db_xref="CDD:285899" Region 302..357 /region_name="TIL" /note="Trypsin Inhibitor like cysteine rich domain; pfam01826" /db_xref="CDD:280072" Region 359..>403 /region_name="VWC_out" /note="von Willebrand factor (vWF) type C domain; smart00215" /db_xref="CDD:214565" Region 386..549 /region_name="VWD" /note="von Willebrand factor (vWF) type D domain; smart00216" /db_xref="CDD:214566" Region 588..660 /region_name="C8" /note="C8 domain; pfam08742" /db_xref="CDD:285899" Region 664..721 /region_name="TIL" /note="Trypsin Inhibitor like cysteine rich domain; pfam01826" /db_xref="CDD:280072" Region 782..827 /region_name="TIL" /note="Trypsin Inhibitor like cysteine rich domain; pfam01826" /db_xref="CDD:280072" Region 829..886 /region_name="VWC" /note="von Willebrand factor type C domain; cl17735" /db_xref="CDD:302663" Region 868..1017 /region_name="VWD" /note="von Willebrand factor type D domain; pfam00094" /db_xref="CDD:278521" Region 1057..1127 /region_name="C8" /note="C8 domain; pfam08742" /db_xref="CDD:285899" Region 1561..1738 /region_name="1, truncated" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q6W4X9.3)" Region 1607..1953 /region_name="Approximate repeats" /experiment="experimental evidence, no additional details recorded" /note="propagated from UniProtKB/Swiss-Prot (Q6W4X9.3)" Region 2188..>2343 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region 2351..2434 /region_name="CT" /note="C-terminal cystine knot-like domain (CTCK); smart00041" /db_xref="CDD:214482" CDS 1..2439 /gene="MUC6" /gene_synonym="MUC-6" /coded_by="NM_005961.2:52..7371" /db_xref="CCDS:CCDS44513.1" /db_xref="GeneID:4588" /db_xref="HGNC:HGNC:7517" /db_xref="MIM:158374" ORIGIN 1 mvqrwlllsc cgallsagla ntsytspglq rlkdspqtap dkgqcstwga ghfstfdhhv 61 ydfsgtcnyi faatckdafp tfsvqlrrgp dgsisriive lgasvvtvse aiisvkdigv 121 islpytsngl qitpfgqsvr lvakqlelel evvwgpdshl mvlverkymg qmcglcgnfd 181 gkvtnefvse egkflephkf aalqklddpg eictfqdips thvrqaqhar ictqlltlva 241 pecsvskepf vlscqadvaa apqpgpqnss catlseysrq csmvgqpvrr wrspglcsvg 301 qcpanqvyqe cgsacvktcs npqhscsssc tfgcfcpegt vlndlsnnht cvpvtqcpcv 361 lhgamyapge vtiaacqtcr ctlgrwvcte rpcpghcsle ggsfvttfda rpyrfhgtct 421 yillqspqlp edgalmavyd ksgvshsets lvavvylsrq dkivisqdev vtnngeakwl 481 pyktrnitvf rqtsthlqma tsfglelvvq lrpifqayvt vgpqfrgqtr glcgnfngdt 541 tddfttsmgi aegtaslfvd swragncpaa leretdpcsm sqlnkvcaet hcsmllrtgt 601 vferchatvn papfykrcvy qacnyeetfp hicaalgdyv hacslrgvll wgwrssvdnc 661 tipctgnttf synsqacert clslsdrate chhsavpvdg cncpdgtyln qkgecvrkaq 721 cpcilegykf ilaeqstvin gitchcingr lscpqrpqmf lascqapktf kscsqssenk 781 fgaacaptcq mlatgvacvp tkcepgcvca eglyenadgq cvppeecpce fsgvsypgga 841 elhtdcrtcs csrgrwacqq gthcpstctl ygeghvitfd gqrfvfdgnc eyilatdvcg 901 vndsqptfki ltenvicgns gvtcsraiki flgglsvvla drnytvtgee phvqlgvtpg 961 alslvvdisi pgrynltliw nrhmtiliri arasqdplcg lcgnfngnmk ddfetrsryv 1021 asselelvns wkesplcgdv sfvtdpcsln afrrswaerk csvinsqtfa tchskvyhlp 1081 yyeacvrdac gcdsggdcec lcdavaayaq acldkgvcvd wrtpafcpiy cgfynthtqd 1141 ghgeyqytqe anctwhyqpc lcpsqpqsvp gsniegcync sqdeyfdhee gvcvpcmppt 1201 tpqppttpql pttgsrptqv wpmtgtstti gllsstgpsp ssnhtpaspt qtpllpatlt 1261 sskptassge pprpttavtp qatsglppta tlrstatkpt vtqattrata staspattst 1321 aqsttrttmt lptpatsgts ptlpkstnqe lpgttatqtt gprptpastt gpttpqpgqp 1381 trptatettq trttteyttp qtphtthspp tagspvpstg pvtatsfhat ttyptpshpe 1441 ttlpthvppf stslvtpsth tvitpthaqm atsasnhsap tgtipppttl katgsthtap 1501 pitpttsgts qahssfstnk tptslhshts sthhpevtpt stttitpnpt strtrtpvah 1561 tnsatssrpp ppftthsppt gsspfsstgp mtatsfkttt typtpshpqt tlpthvppfs 1621 tslvtpstht vitpthaqma tsasihsmpt gtipppttlk atgsthtapt mtlttsgtsq 1681 alsslntakt stslhshtss thhaeatsts ttnitpnpts tgtppmtvtt sgtsqsrssf 1741 staktstslh shtssthhpe vtststtsit pnhtstgtrt pvahttsats srlptpftth 1801 spptgttpis stgpvtatsf qttttyptps hphttlpthv psfstslvtp sthtviipth 1861 tqmatsasih smptgtippp ttikatgsth tappmtptts gtsqspssfs taktstslpy 1921 htssthhpev tptsttnitp khtstgtrtp vahttsasss rlptpftths pptgsspfss 1981 tgpmtatsfq ttttyptpsh pqttlpthvp pfstslvtps thtviittht qmatsasihs 2041 tptgtvpppt tlkatgstht appmtvttsg tsqthssfst atasssfiss sswlpqnsss 2101 rppsspittq lphlssattp vsttnqlsss fspspsapst vssyvpsshs spqtsspsvg 2161 tsssfvsapv hsttlssgsh sslsthptta svsasplfps spaasttira tlphtisspf 2221 tlsallpist vtvsptpssh lasstiafps tprttastht apafssqstt srstslttrv 2281 ptsgfvslts gvtgiptspv tnlttrhpgp tlspttrflt ssltahgstp asapvsslgt 2341 ptptspgvcs vreqqeeitf kgcmanvtvt rcegacisaa sfniitqqvd arcsccrplh 2401 syeqqlelpc pdpstpgrrl vltlqvfshc vcssvacgd //
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