MUC9 tietämystä referaattien ja peptidisekvenssin peruteella. Tutkimukset ovat aiemmin kohdistuneet reproduktioalueeseen ja viimeisimmät suoliston alueen tutkimuksiin.
2012, Referaatti 1. MUC9- geenin ilmenemän havaittiin alentuneen aktiivissa ja remissiossa olevassa haavaisessa paksunsuolentulehduksessa (UC).Biopsiatutkimus.
2010, Referaatti 2. Geneettisiin tutkimuksiin sisällytetty myös tämä geeni katsottaessa pitkäikäisyyteen vaikuttavaa geenitaustaa.
2010, Referaatti 3 .Oviduktaalinen glykoproteiini (OVGP1, MUC9): Erilaistumiseen perustuva musiini esiintyy ovariaalisyöpää sairastavien naisten seerumissa.
2008, Refereaatti 4. Musiinigeenien ilmenemä ihmisen kurkunpään epiteelillä: vaikutusta laryngofaryngeaaliseen refluksiin. Refluxlryngiittiin liittyy musiinigeenien alassäätymä.
2006, Referaatti 5. OGP:n sitoutuminen gameetteihin välittyy MYH:n kautta OGP:n ei-glykosyloituneeseen N-terminaaliin, jaksoon 11-137. On tunnistettu ja luonnehdittu oviduktaalia glykoproteiinia gameeteissa sitova partneri: epitooppien samankaltaisuutta ei-lihasmyosiiniin IIa (MYH9)
2002, Referaatti 6. Oviduktiinin korkein ilmenemä asettuu ovulaatioon, mikä on yhtä pitävää sen osuuteen fertilisaatiossa ja embryon alkeiskehityksess.
2002, Referaatti 7. Ihmisen oviduktaaligeenin promoottorin kloonaus ja luonnehdinta.
1997, Referaatti 8. Ihmisen oviduktaaligeenin (MUC9) alleelipolymorfia ja kromosomaalisijainti.
1994, Referaatti 9. Ihmisen estrogeenista riippuvan oviduktaalisen glykoproteiinin komplementaarisen DNA.n kloonaus ja molekulaarinen luonnehdinta.
1988, Referaatti 10. Oviduktaalien proteiinien in vitro synteesistä ja erittymisestä.
oviduct-specific glycoprotein precursor [Homo sapiens]
NCBI Reference Sequence: NP_002548.3
LOCUS NP_002548 678 aa linear PRI 15-SEP-2018 DEFINITION oviduct-specific glycoprotein precursor [Homo sapiens]. ACCESSION NP_002548 VERSION NP_002548.3 DBSOURCE REFSEQ: accession NM_002557.3 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 678) AUTHORS Yamamoto-Furusho,J.K., Mendivil,E.J. and Fonseca-Camarillo,G. TITLE Reduced expression of mucin 9 (MUC9) in patients with ulcerative colitis JOURNAL Inflamm. Bowel Dis. 18 (3), E601 (2012) PUBMED 22028245 REMARK GeneRIF: Decreased gene expression of MUC9 was found from colonic biopsies in patients with active and remission ulcerative colitis. Erratum:[Inflamm Bowel Dis. 2015 Nov;21(11):2735. Mendivil-Rangel, Edgar J [corrected to Mendivil, Edgar J]] REFERENCE 2 (residues 1 to 678) AUTHORS Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanche H, Schreiber S and Nebel A. TITLE Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study JOURNAL Mutat. Res. 694 (1-2), 13-19 (2010) PUBMED 20800603 REMARK GeneRIF: Observational study of gene-disease association. (HuGE Navigator) REFERENCE 3 (residues 1 to 678) AUTHORS Maines-Bandiera S, Woo MM, Borugian M, Molday LL, Hii T, Gilks B, Leung PC, Molday RS and Auersperg N. TITLE Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin present in serum of women with ovarian cancer JOURNAL Int. J. Gynecol. Cancer 20 (1), 16-22 (2010) PUBMED 20130498 REMARK GeneRIF: OVGP1 seems to detect a different spectrum of ovarian epithelial cancers than other markers and thus should be a useful adjunct for more accurate detection, particularly of early serous ovarian cancers and mucinous carcinomas. REFERENCE 4 (residues 1 to 678) AUTHORS Samuels TL, Handler E, Syring ML, Pajewski NM, Blumin JH, Kerschner JE and Johnston N. TITLE Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux JOURNAL Ann. Otol. Rhinol. Laryngol. 117 (9), 688-695 (2008) PUBMED 18834073 REMARK GeneRIF: Reflux laryngitis is associated with down-regulation of mucin gene expression. REFERENCE 5 (residues 1 to 678) AUTHORS Kadam KM, D'Souza SJ, Bandivdekar AH and Natraj U. TITLE Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9 JOURNAL Mol. Hum. Reprod. 12 (4), 275-282 (2006) PUBMED 16567366 REMARK GeneRIF: Results suggests the binding of OGP to human sperm mediates through MYH9.OGP binds to both gametes through its interaction with MYH9 through the non-glycosylated N-terminal conserved region of OGP, spanning the residues 11-137. REFERENCE 6 (residues 1 to 678) AUTHORS Lok IH, Briton-Jones CM, Yuen PM and Haines CJ. TITLE Variable expression of oviductin mRNA at different stages of human reproductive cycle JOURNAL J. Assist. Reprod. Genet. 19 (12), 569-576 (2002) PUBMED 12503889 REMARK GeneRIF: The production and function of oviductin at different stages of human reproductive cycle is not well known. Its highest expression at the time of ovulation is consistent with a supportive role in fertilization and early embryo development. REFERENCE 7 (residues 1 to 678) AUTHORS Agarwal A, Yeung WS and Lee KF. TITLE Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter JOURNAL Mol. Hum. Reprod. 8 (2), 167-175 (2002) PUBMED 11818519 REMARK GeneRIF: cloning and characterization of the promoter and gene expression regulation in the oviduct (human oviduct-specific glycoprotein, HuOPG) REFERENCE 8 (residues 1 to 678) AUTHORS Lapensee L, Paquette Y and Bleau G. TITLE Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9) JOURNAL Fertil. Steril. 68 (4), 702-708 (1997) PUBMED 9341614 REFERENCE 9 (residues 1 to 678) AUTHORS Arias EB, Verhage HG and Jaffe RC. TITLE Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein JOURNAL Biol. Reprod. 51 (4), 685-694 (1994) PUBMED 7819450 REFERENCE 10 (residues 1 to 678) AUTHORS Verhage HG, Fazleabas AT and Donnelly K. TITLE The in vitro synthesis and release of proteins
by the human oviduct JOURNAL Endocrinology 122 (4), 1639-1645 (1988) PUBMED 3278893 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY189737.1, U09550.1 and AA909093.1. This sequence is a reference standard in the RefSeqGene project. On Feb 1, 2005 this sequence version replaced NP_002548.2. Summary: This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U09550.1, AY189737.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..678 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="1" /map="1p13.2" Protein 1..678 /product="oviduct-specific glycoprotein precursor" /note="mucin 9; estrogen-dependent oviduct protein; oviductal glycoprotein 1, 120kDa; oviductin; oviduct-specific glycoprotein; oviduct glycoprotein" /calculated_mol_wt=73040 sig_peptide 1..21 /inference="COORDINATES: ab initio prediction:SignalP:4.0" /calculated_mol_wt=2400 Region 24..382 /region_name="GH18_chitolectin_chitotriosidase" /note="This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active...; cd02872" /db_xref="CDD:119351" Site order(27y,31w,100w..101n,139f,141L..142y,187g..188v,211 L,213y..214d, 219w,263y,265r,293q,355w) /site_type="active" /db_xref="CDD:119351" Region <368 ..557="" cdd="" cddsrv.cgi="" db_xref="CDD:<a href=" https:="" note="<b>Predicted periplasmic protein [Function unknown</b>]" region_name="<b>COG3889</b>" tructure="" uid="226406" www.ncbi.nlm.nih.gov="">226406
<368 ..557="" cdd="" cddsrv.cgi="" db_xref="CDD:<a href=" https:="" note="<b>Predicted periplasmic protein [Function unknown</b>]" region_name="<b>COG3889</b>" tructure="" uid="226406" www.ncbi.nlm.nih.gov="">
"
CDS 1..678
/gene="OVGP1"
/gene_synonym="CHIT5; EGP; MUC9; OGP"
/coded_by="NM_002557.3:57..2093"
/db_xref="CCDS:CCDS834.1"
/db_xref="GeneID:5016"
/db_xref="HGNC:HGNC:8524"
/db_xref="MIM:603578" ORIGIN
1 mwklllwvgl vlvlkhhdga ahklvcyftn wahsrpgpas ilphdldpfl cthlifafas
61 mnnnqivakd lqdekilype fnklkernre lktllsiggw nfgtsrfttm lstfanrekf
121 iasvisllrt hdfdgldlff lypglrgspm hdrwtflfli eellfafrke alltmrprll
181 lsaavsgvph ivqtsydvrf lgrlldfinv lsydlhgswe rftghnsplf slpedpkssa
241 yamnywrklg apseklimgi ptygrtfrll kasknglqar aigpaspgky tkqegflayf
301 eicsfvwgak khwidyqyvp yankgkewvg ydnaisfsyk awfirrehfg gamvwtldmd
361 dvrgtfcgtg pfplvyvlnd ilvraefsst slpqfwlssa vnssstdper lavttawttd
421 skilppggea gvteihgkce nmtitprgtt vtptketvsl gkhtvalgek teitgamtmt
481 svghqsmtpg ekaltpvghq svttgqktlt svgyqsvtpg ektltpvghq svtpvshqsv
541 spggttmtpv hfqtetlrqn tvaprrkava rekvtvpsrn isvtpegqtm plrgenltse
601 vgthprmgnl glqmeaenrm mlssspviql peqtplafdn rfvpiygnhs svnsvtpqts
661 plslkkeipe nsavdeea //
(Rakenteessa on muutama LxxLL- tyyppinen säätelykohta kitolektiiniosassa.
Tmmennettuna on jakso, jonka " funktio on tuntematon".
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