MUC-24, CD164 (6q21) , DFNA66, endolyn, MGC-24, sialomucin

 CD164, sialomusiini,  MUC-24 on hematopoeeettisen progeniittorin vahva negatiivinen säätelijä.

https://www.ncbi.nlm.nih.gov/gene/8763
https://www.uniprot.org/uniprot/Q04900

Also known as

DFNA66; MGC-24; MUC-24; MGC-24v; endolyn

Summary

This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

Expression

Ubiquitous expression in thyroid (RPKM 246.6), fat (RPKM 191.2) and 25 other tissues See more

Related articles in PubMed

1. MicroRNA-124 suppresses tumor cell proliferation and invasion by targeting CD164 signaling pathway in non-small cell lung cancer. Lin J, et al. J Gene Ther, 2016 Feb. PMID 27376157, Free PMC Article
2. Expression of CD164 on Malignant T cells in Sézary Syndrome. Guenova E, et al. Acta Derm Venereol, 2016 May. PMID 26524186
3. CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. Wysocka M, et al. J Invest Dermatol, 2014 Jan. PMID 23792457, Free PMC Article
4. Inhibiting CD164 expression in colon cancer cell line HCT116 leads to reduced cancer cell proliferation, mobility, and metastasis in vitro and in vivo. Tang J, et al. Cancer Invest, 2012 Jun. PMID 22409183
5. Cis-regulatory functions of overlapping HIF-1alpha/E-box/AP-1-like sequences of CD164. Tang J, et al. BMC Mol Biol, 2011 Oct 14. PMID 21999799, Free PMC Article

GeneRIFs: Gene References Into Functions

1. CD164 expression may have affected the proliferation and apoptosis of human glioma cells via the PTEN/phosphoinositide 3-kinase/AKT pathway.
2. The expression of Sezary signature genes: FCRL3, Tox, and miR-214, was significantly higher in samples from Sezary syndrome patients with CD164 expressing CD4(+) T cells.
3. In a cohort of patients with Sezary syndrome, CD164 expression on total CD4+ lymphocytes was significantly upregulated compared with healthy controls. CD164 expression was in most cases limited to CD4+CD26- malignant T lymphocytes.
4. This paper identified a new Deafness, Autosomal Dominant locus located on chromosome 6q15-21 and implicated CD164 as a novel gene for hearing impairment.
5. miR-219 inhibits the proliferation, migration and invasion of medulloblastoma cells by targeting CD164.
6. Increased expression of CD164 is involved in ovarian cancer progression via the SDF-1alpha/CXCR4 axis.
7. CD164 is highly expressed in the colon cancer sites, and it promotes HCT116 colon cancer cell proliferation and metastasis both in vitro and in vivo
8. C-jun and HIF-1alpha bound to the CD164 promoter region and activated the CD164 expression.
9. Conclude that assessment of allergen-induced basophil CD164 upregulation is a very useful method for in vitro determination of allergy to grass pollens.
10. Data identify CD13, CD107a, and CD164 as novel basophil-activation antigens.

Rakenne: 

https://www.ncbi.nlm.nih.gov/protein/NP_001135873.1