- Also known as
- NEDD10; FP13169
- Expression
- Ubiquitous expression in ovary (RPKM 1.9), kidney (RPKM 1.8) and 25 other tissues See more
- Orthologs
- mouse all
- Preferred Names
- zinc finger protein 618
- Names
- neural precursor cell expressed, developmentally down-regulated 10
- Conserved Domains (2) summary
-
- pfam09595
Location:250 → 358 - Metaviral_G; Metaviral_G glycoprotein
- sd00017
Location:117 → 137 - ZF_C2H2; C2H2 Zn finger [structural motif]
- pfam09595
- Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader. Liu Y, et al. J Biol Chem, 2016 Jun 24. PMID 27129234, Free PMC Article 5-Hydroxymethylcytosine (5hmC) is an epigenetic modification that is generated by ten-eleven translocation (TET) protein-mediated oxidation of 5-methylcytosine (5mC). 5hmC is associated with transcription regulation and is decreased in many cancers including melanoma. Accumulating evidence has suggested that 5hmC is functionally distinct from 5mC. Ubiquitin-like with PHD and ring finger domains 2 (UHRF2) is the first known specific 5hmC reader that has higher affinity to 5hmC than 5mC, suggesting that UHRF2 might mediate 5hmC's function. Structural analysis has revealed the molecular mechanism of UHRF2-5hmC binding in vitro, but it is not clear how UHRF2 recognizes 5hmC in vivo In this study, we have identified zinc figure protein 618 (ZNF618) as a novel binding partner of UHRF2. ZNF618 specifically interacts with UHRF2 but not its paralog UHRF1. Importantly, ZNF618 co-localizes with UHRF2 at genomic loci that are enriched for 5hmC. The ZNF618 chromatin localization is independent of its interaction with UHRF2 and is through its first two zinc fingers. Instead, ZNF618 regulates UHRF2 chromatin localization. Collectively, our study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
- Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. Letra A, et al. Am J Med Genet A, 2010 Jul. PMID 20583170, Free PMC Article
- Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2009 Oct. PMID 19724895
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. Nagase T, et al. DNA Res, 2001 Dec 31. PMID 11853319
- Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296
GeneRIFs: Gene References Into Functions
- study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
- Observational study of gene-disease association. (HuGE Navigator)
Inga kommentarer:
Skicka en kommentar