SENP1 (12q13.11) Desumoylaasi , sentriinispesifinen cysteiiniproteaasi 1

SENP1(12q13.11), SuPr-2
https://www.ncbi.nlm.nih.gov/gene/29843

Preferred Names

sentrin-specific protease 1

Names

SUMO1/sentrin specific peptidase 1

SUMO1/sentrin specific protease 1

sentrin/SUMO-specific protease SENP1

mRNA and Protein(s) 

NLS: pkktqrr, kkrk, pyfrkrm

NES: vweilhrkll

NR site: llqyl?

NM_001267594.2 → NP_001254523.1  sentrin-specific protease 1

ORIGIN      
        1 mddiadrmrm dagevtlvnh nsvfkthllp qtgfpedqls lsdqqilssr qghldrsftc
       61 strsaaynps yysdnpssds flgsgdlrtf gqsangqwrn stpssssslq ksrnsrslyl
      121 etrktssgls nsfagksnhh chvsayeksf pikpvpspsw sgscrrslls pkktqrrhvs
      181 taeetvqeee reiyrqllqm vtgkqftiak ptthfplhls rclssskntl kdslfkngns
      241 casqiigsdt sssgsasilt nqeqlshsvy slssytpdva fgskdsgtlh hphhhhsvph
      301 qpdnlaasnt qsegsdsvil lkvkdsqtpt psstffqael wikeltsvyd srarerlrqi
      361 eeqkalalql qnqrlqereh svhdsvelhl rvplekeipv tvvqetqkkg hkltdsedef
      421 peiteemeke iknvfrngnq devlseafrl titrkdiqtl nhlnwlndei infymnmlme
      481 rskekglpsv hafntffftk lktagyqavk rwtkkvdvfs vdillvpihl gvhwclavvd
      541 frkknityyd smgginneac rillqylkqe sidkkrkefd tngwqlfskk sqeipqqmng
      601 sdcgmfacky adcitkdrpi nftqqhmpyf rkrmvweilh rkll

Conserved Domains (1) summary

cl23802
Location:420 → 642

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

1. SUMO protease SENP1 deSUMOylates and stabilizes c-Myc. Sun XX, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30305424, Free PMC Article
2. Overexpression of SENP1 reduces the stemness capacity of osteosarcoma stem cells and increases their sensitivity to HSVtk/GCV. Liu F, et al. Int J Oncol, 2018 Nov. PMID 30226577, Free PMC Article
3. Small ubiquitin-like modifier/sentrin-specific peptidase 1 associates with chemotherapy and is a risk factor for poor prognosis of non-small cell lung cancer. Liu K, et al. J Clin Lab Anal, 2018 Nov. PMID 30043429
4. SENP1 promotes proliferation of clear cell renal cell carcinoma through activation of glycolysis. Dong B, et al. Oncotarget, 2016 Dec 6. PMID 27741516, Free PMC Article
5. Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-κB/Akt pathways. Xia W, et al. Gene, 2016 Dec 31. PMID 27693211

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

1. It has been proposed that the functional link between chromatin remodeling by CHD3 and deSUMOylation by SENP1 provides another level of control of gene expression.
2. Study revealed a significant decrease in the expression of SUMO1 specific peptidase 1 (SENP1) in osteosarcoma tissues and osteosarcoma cell lines, and SENP1 expression was much lower in osteosarcoma stem cells than in noncancer stem cells.
3. KLF15 is a critical regulator of pulmonary endothelial homeostasis via repression of endothelial Arg2 expression. KLF15 abundance and nuclear compartmentalization are regulated by SUMOylation/deSUMOylation-a hypoxia-sensitive process that is controlled by SENP1.
4. Results in this present study showed that SENP1 was a risk factor for poor non-small cell lung cancer prognosis. And also demonstrated that the overexpression of SENP1 in non-small cell lung cancer was related to chemotherapy resistance.
5. SENP1 is a crucial c-Myc deSUMOylating enzyme that positively regulates c-Myc's stability and activity.
6. endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction.
7. Results showed that the expression of SENP1 was remarkably upregulated in osteosarcoma cells (OS) cells. SENP1 positively regulated HIF-1alpha expression level in the setting of hypoxic; subsequently, its depletion markedly ameliorated VEGF production triggered by hypoxia.
8. These results suggest that the miR-133a-3p-SENP1 axis might play a role in cell proliferation and cell cycle regulation of colorectal cancer cells.
9. Despite the requirement of all three nucleoporins for accurate NHEJ, only Nup153 is needed for proper nuclear import of 53BP1 and SENP1-dependent sumoylation of 53BP1. Data support the role of Nup153 as an important regulator of 53BP1 activity and efficient NHEJ.
10. miR-185 was significantly downregulated in RCC tissues and cell lines. SENP1 was a direct target of miR-186, and SENP1 mRNA expression was reversely correlated with miR-186 in RCC tissues.

Submit: New GeneRIF Correction See all GeneRIFs (65)