Soluvälisignalointisysteemien setti: Notch, EGF, FGF, TGFbeta, Hedgehog ja Wnt. , kuusi signaalinjohtosysteemiä :

Six signal transduction system, notch, EGF, FGF, TGFbeta, Hedgehog, and Wnt, are utilized to provide spatial inputs in a myriad of diverse subcircuits in the development of any bilaterian, and in different contents  in different bilaterians. Though in their internal biochemical interactions these signal transduction cassetes are higly conserved across the bilateria, they are indeed "plugged in" at all levels of gene regulatory networks, in all sorts of regulatory spatial  specification processes.

Lähde:
Eric H. Davidson. 2006.
The Regulatory genome:Gene regulatory network in Development and Evolution.  p. 194.

S. 138:
.. a small set of intercellular signal systems used in developmental, specification processes: for example throughout the bilaterian world Hedgehog, TGFbeta, Wnt, FGF and Notch signaling cassettes are utilized and reutilized in diverse developmental contexts.

The cassette includes in each case  the genes  ( and their regulatory  modules) encoding ligands, the receptors, and the transcription factors which provide the immediaty early responses used to  transduce the intercellular signal at the transcription level in the cell expressing the receptor.

In each of these signaling systems  the cassettes are largely  invariant in their orthologous molecular constitutions, as they appear in different bilaterians, but their target cis-regulatory modules occur in as great variety as the diversity of the jobs they do.  Thus the distinction  betwen the plug-in and the device into  which it is plugged is not in the least obscure.


esim: :

NOTCH modulista
DUB USP 10  hienosäätää  NOTCH:in intrasellularisen NICD1 fraktiota jarruttamalla  ubikitinoitumista  ja täten vaikuttaa  angiogeneesiä .

Deubiquitinase USP10 regulates Notch signaling in the endothelium.Abstract
Notch signaling is a core patterning module for vascular morphogenesis that codetermines the sprouting behavior of endothelial cells (ECs). Tight quantitative and temporal control of Notch activity is essential for vascular development, yet the details of Notch regulation in ECs are incompletely understood.
We found that ubiquitin-specific peptidase 10 (USP10) interacted with the NOTCH1 intracellular domain (NICD1) to slow the ubiquitin-dependent turnover of this short-lived form of the activated NOTCH1 receptor.
 Accordingly, inactivation of USP10 reduced NICD1 abundance and stability and diminished Notch-induced target gene expression in ECs.
 In mice, the loss of endothelial Usp10 increased vessel sprouting and partially restored the patterning defects caused by ectopic expression of NICD1. Thus, USP10 functions as an NICD1 deubiquitinase that fine-tunes endothelial Notch responses during angiogenic sprouting.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S.


USP10, (16q24.1), https://www.ncbi.nlm.nih.gov/gene/9100, UBPO (cofactor of DNA-bound androgenreceptor complex);