WDR perheestä: 277 proteiinia . Ensin WDR40 (DCAF12) (9p13.3), TCC52, KIAA1892, CT102.

 WDR40, DCAF12, (9p13.3 )https://www.ncbi.nlm.nih.gov/gene/25853

Official Symbol

DCAF12provided by HGNC

Official Full Name

DDB1 and CUL4 associated factor 12

Also known as

CT102; TCC52; WDR40A; KIAA1892

Summary

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

Expression

Broad expression in testis (RPKM 38.2), lymph node (RPKM 19.3) and 25 other tissues See more

Orthologs

mouse all

Preferred Names

DDB1- and CUL4-associated factor 12

Names

WD repeat domain 40A

WD repeat-containing protein 40A

cancer/testis antigen 102

centrosome-related protein TCC52

testis cancer centrosome-related protein

  NP_056212.1  DDB1- and CUL4-associated factor 12 ( info about the peptide and its regions) 

 Ex.region WD1  

erefhlgtln kvfasqwlnh rqvvcgtkcn tlfvvdvqts qi

 region WD6 

 sllfyd

ORIGIN      
        1 markvvsrkr kapaspgags daqgpqfgwd hslhkrkrlp pvkrslvyyl knrevrlqne
       61 tsysrvlhgy aaqqlpsllk erefhlgtln kvfasqwlnh rqvvcgtkcn tlfvvdvqts
      121 qitkipilkd repggvtqqg cgihaielnp srtllatggd npnslaiyrl ptldpvcvgd
      181 dghkdwifsi awisdtmavs gsrdgsmglw evtddvltks darhnvsrvp vyahithkal
      241 kdipkedtnp dnckvralaf nnknkelgav sldgyfhlwk aentlsklls tklpycrenv
      301 claygsewsv yavgsqahvs fldprqpsyn vksvcsrerg sgirsvsfye hiitvgtgqg
      361 sllfydiraq rfleerlsac ygskprlage nlklttgkgw lnhdetwrny fsdidffpna
      421 vythcydssg tklfvaggpl psglhgnyag lws

 

Conserved Domains (2) summary

sd00039
Location:137 → 180

7WD40; WD40 repeat [structural motif]

WD40 repeats in seven bladed beta propellers

The WD40 repeat is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing, and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD dipeptides lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel beta-sheet. The WD40 sequence repeat originally described in literature forms the first three strands of one blade and the last strand in the next blade. The C-terminal WD40 repeat completes the blade structure of the N-terminal WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands, allowing them to bind either stably or reversibly.

cl25539
Location:85 → 279

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues  from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

 

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Of the classifier's 11 informative genes, expression of MIR and WDR40 showed statistically significant increases for both Grade 1B and Grade >or=3A rejection.
2. TCC52, as a novel CT antigen, would be a promising candidate for cancer immunotherapy.

DCAF- perhe löytyi. Ne ovat  cullin-RING  E3- komplekseja, jotka  ovat poikkeavia  kokoontumistavoiltaan, sillä niistä puuttuu SKP1- kaltainen cullin- adaptori ja määritetty substraattia rekrytoiva domeeni.  Niistä löytyi WDR rakennetta., joka sitoutuu suoraan  DDB1:n kaksoispropellipoimuun. Tämä WDR40 ob DCAF12.
https://www.ncbi.nlm.nih.gov/pubmed/16964240/