- CRIPT textmining
- https://string-db.org/network/9606.ENSP00000394248
- tässä ylläolevassa string lätheessä on kuva, jossa on interaktion viiva ZNF716 ja CRIPT kesken.
- GenPept
- ZNF716
- Conserved Domains (6) summary
-
- smart00349
Location:16 → 76 - KRAB; krueppel associated box
- COG5048
Location:211 → 494 - COG5048; FOG: Zn-finger [General function prediction only]
- sd00017
Location:298 → 318 - ZF_C2H2; C2H2 Zn finger [structural motif]The C2H2 zinc finger is a classical zinc finger domain. C2H2-type zinc fingers are ubiquitous; more than 1% of all mammalian proteins are predicted to contain at least one zinc finger. They often function as DNA or protein binding structural motifs, such as in eukaryotic transcription factors, and therefore they play important roles in cellular processes such as development, differentiation, and oncosuppression. C2H2 zinc finger proteins contain from 1 to more than 30 zinc finger repeats.
- pfam01352
Location:16 → 55 - KRAB; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
- pfam13465
Location:228 → 251 - zf-H2C2_2; Zinc-finger double domain
- pfam14353
Location:353 → 398 - CpXC; CpXC protein
- smart00349
zinc finger protein 716 [Homo sapiens]
NCBI Reference Sequence: NP_001152751.1
LOCUS NP_001152751 495 aa linear PRI 01-MAY-2019 DEFINITION zinc finger protein 716 [Homo sapiens]. ACCESSION NP_001152751 XP_001714706 XP_001714722 XP_001719254 XP_943217 VERSION NP_001152751.1 DBSOURCE REFSEQ: accession NM_001159279.1 KEYWORDS RefSeq; RefSeq Select. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 495) AUTHORS Simino J, Sung YJ, Kume R, Schwander K and Rao DC. TITLE Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9 JOURNAL Front Genet 4, 277 (2013) PUBMED 24376456 REMARK Publication Status: Online-Only COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK131575.1 and AC092175.5. On or before Apr 14, 2009 this sequence version replaced XP_001714706.1, XP_001714722.1, XP_943217.3, XP_001719254.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK131575.1, DB064525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..495 /organism="Homo sapiens" /db_xref="taxon:9606" /chromosome="7" /map="7p11.2" Protein 1..495 /product="zinc finger protein 716" /calculated_mol_wt=56875 Region 16..76 /region_name="KRAB" /note="krueppel associated box; smart00349" /db_xref="CDD:214630" Region 16..55 /region_name="KRAB" /note="KRAB box; pfam01352" /db_xref="CDD:279668" Region 160..179 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 187..207 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(187,190,203,207) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 211..>494 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 215..235 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(215,218,231,235) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 228..251 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 243..263 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(243,246,259,263) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 283..307 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 298..318 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(298,301,314,318) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Site order(303,305,307,309..310,313..314,317,331,333,337..338, 341..342,345,359,361,363,365..366,369..370,373) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 311..334 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 326..346 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(326,329,342,346) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 353..>398 /region_name="CpXC" /note="CpXC protein; pfam14353" /db_xref="CDD:291051" Region 354..374 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(354,357,370,374) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 382..402 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(382,385,398,402) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 398..419 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 410..430 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(410,413,426,430) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 423..446 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 438..458 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(438,441,454,458) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 451..474 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:290200" Region 466..486 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(466,469,482,486) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" CDS 1..495 /gene="ZNF716" /coded_by="NM_001159279.1:113..1600" /db_xref="CCDS:CCDS55112.1" /db_xref="GeneID:441234" /db_xref="HGNC:HGNC:32458" ORIGIN 1 makrpgppgs remglltfrd iaiefslaew qcldhaqqnl yrdvmlenyr nlvslgiavs 61 kpdlitcleq nkepqnikrn emvakhpvtc shftqdlqse qgikdslqkv ilrrygkcgq 121 edlqvkkcck svgecevhkg gynyvnqcls atqnktfqth kcvkvfgkfs nsnrhktrht 181 gkkhfkcknd gksfcmlsrl nqhqiihtre ksykceecgk sfncsstltr hkrihtgekp 241 yrceecgkaf swsasltkhk rihtgekpyt ceergkvfsr stltnykrih tgekpytcee 301 cgkafsrsst ltnhkrihtg erpykceecg kafslsstlk khkivhtgek lytceecgka 361 ftfsstlnth krihtgekpy tceecgkafs lpstftyhkr thtgekpykc eecgkafncs 421 stlkkhkiih tgeklykcke cgkaftfsst lnthkrihtg ekpykceecd qtfkwhssla 481 nhknmhtgek pykye //
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