- Also known as
- CSN2; SGN2; ALIEN; TRIP15
- Expression
- Ubiquitous expression in bone marrow (RPKM 22.3), thyroid (RPKM 19.6) and 25 other tissues See more
- Orthologs mouse all
- Preferred Names
- COP9 signalosome complex subunit 2
- Names
- COP9 constitutive photomorphogenic homolog subunit 2
- JAB1-containing signalosome subunit 2
- TR-interacting protein 15
- TRIP-15
- alien homolog
- signalosome subunit 2
- thyroid receptor-interacting protein 15
Related articles in PubMed
- Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy. Pearce C, et al. BMC Cell Biol, 2009 Apr 28. PMID 19400951, Free PMC Article
- The coregulator Alien. Papaioannou M, et al. Nucl Recept Signal, 2007 Nov 30. PMID 18174916, Free PMC Article
- Alien inhibits E2F1 gene expression and cell proliferation. Tenbaum SP, et al. Biochim Biophys Acta, 2007 Sep. PMID 17570542
- Interaction of the corepressor Alien with DAX-1 is abrogated by mutations of DAX-1 involved in adrenal hypoplasia congenita. Altincicek B, et al. J Biol Chem, 2000 Mar 17. PMID 10713076
- Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation. Zhang M, et al. Atherosclerosis, 2016 May. PMID 27017521
GeneRIFs: Gene References Into Functions
- Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway.
- AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2-mediated degradation so as to prevent foam cell formation
- CSN2 knockdown cells underwent non-apoptotic cell death.
- p300 binds to Alien alpha by pull down (View interaction) Alien alpha physically interacts with CBP by two hybrid
- A subunit of the COP9 signalosome interacted physically with the anaphase-promoting complex and showed a genetic instability of cells.
- CSN2 gene was identified in the genome-wide loss-of-function genetic screen as putative tumor suppressor located at 15q21.2.
- Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly.
- the interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network
- Alien inhibits E2F1 gene expression and cell proliferation.
- Alien and Sin3A reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24) promoter containing vitamin D3 response elements by chromatin immunoprecipitation
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