COPS8 (2q37.3), CSN8, SGN8. Omaa JAB-1 alayksikön. Kuuluu COP9 signalosomiin alayksikkönä.

 https://www.ncbi.nlm.nih.gov/gene/10920

 

Also known as

COP9; CSN8; SGN8

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Expression

Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues See more

 

NM_198189.2 → NP_937832.1  COP9 signalosome complex subunit 8 isoform 2

            Summary: The protein encoded by this gene is one of the eight
            subunits of COP9 signalosome, a highly conserved protein complex
            that functions as an important regulator in multiple signaling
            pathways. The structure and function of COP9 signalosome is similar
            to that of the 19S regulatory particle of 26S proteasome. COP9
            signalosome has been shown to interact with SCF-type E3 ubiquitin
            ligases and act as a positive regulator of E3 ubiquitin ligases.
            Alternatively spliced transcript variants encoding distinct
            isoforms have been observed. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains an additional exon
            compared to variant 1, resulting in translation initiation from a
            downstream start codon and an isoform (2) with a shorter N-terminus
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.56355.1,
                                           SRR1803616.61119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]

Preferred Names

COP9 signalosome complex subunit 8

Names

COP9 constitutive photomorphogenic homolog subunit 8

COP9 homolog

JAB1-containing signalosome subunit 8

hCOP9

signalosome subunit 8

(Huom. CSN5 on JAMM ryhmää JAB1. Myös tämä alayksikkö CSN8 (2q37.3)   omaa JAB1 , mutta sitä ei kuitenkaan luetella JAMM DUB- luettelossa, kuten  CSN5 (8q13-1. ).