- https://www.ncbi.nlm.nih.gov/gene/26168
- Official Symbol
- SENP3, provided by HGNC
- Official Full Name
- SUMO specific peptidase 3, provided by HGNC
- Also known as
- SSP3; Ulp1; SMT3IP1
- Summary
- The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
- Expression. Ubiquitous expression in testis (RPKM 20.2), brain (RPKM 14.1) and 25 other tissues Se
- Preferred Names
- sentrin-specific protease 3
- Names
- SUMO-1-specific protease 3
- SUMO1/sentrin/SMT3 specific peptidase 3
- sentrin/SUMO-specific protease 3
- NM_015670.6 → NP_056485.2 sentrin-specific protease 3
- Conserved Domains (1) summary
-
- pfam02902
Location:400 → 572 - Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
- pfam02902
- Upregulation of SENP3/SMT3IP1 promotes epithelial ovarian cancer progression and forecasts poor prognosis. Cheng J, et al. Tumour Biol, 2017 Mar. PMID 28351334
- SUMO-specific protease 3 is a key regulator for hepatic lipid metabolism in non-alcoholic fatty liver disease. Liu Y, et al. Sci Rep, 2016 Nov 17. PMID 27853276, Free PMC Article
- Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation. Sun Z, et al. Oncol Rep, 2013 May. PMID 23467634, Free PMC Article
- Mitotic Phosphorylation of SENP3 Regulates DeSUMOylation of Chromosome-Associated Proteins and Chromosome Stability. Wei B, et al. Cancer Res, 2018 May 1. PMID 29438989
- SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Zhou Z, et al. Oncogene, 2016 Nov 10. PMID 27181202, Free PMC Article
GeneRIFs: Gene References Into Functions
- we provide the first direct evidence that SENP3 upregulation pivotally contributes to myocardial ischemia reperfusion (MIR) injury in a Drp1-dependent manner, and suggest that SENP3 suppression may hold therapeutic promise for constraining MIR injury.
- SENP3 phosphorylation decreased its interaction with Topo II alpha, resulting in reduced SENP3 deSUMOylation activity on Topo II alpha. Furthermore, we observed mitotic arrest, increased chromosome instability, and promotion of tumorigenesis in cells expressing a nonphosphorylatable SENP3 mutant
- Data show that increasing dynamin-related protein 1 (Drp1) SUMOylation by knocking down SUMO1-sentrin-SMT3 specific protease 3 (SENP3) reduces both Drp1 binding to mitochondrial fission factor protein (Mff) and stress-induced cytochrome c release.
- Important role of SENP3 in lipid metabolism during the development of non-alcoholic fatty liver disease.
- SENP3 knockdown reduced cadmium-induced caspase 3 cleavage and cell death in PC12 cells, while SENP3 overexpression enhanced cell death.
- Our data identified SUMOylation as a previously undescribed post-translational modification of STAT3 and SENP3 as a critical positive modulator of tobacco- or cytokine-induced STAT3 activation.
- The data demonstrate that SUMO2 conjugation and SENP3-driven deSUMOylation of PELP1 is instrumental for ordered progression of ribosome maturation, and they provide molecular insight into the dynamics of ribosome maturation.
- our findings for the first time specifically supported that SUMO-specific protease 3 might play an important role in the regulation of epithelial ovarian cancer progression and could serve as a potential biomarker for prognosis as well as provide a promising therapeutic target against epithelial ovarian cancer
- In early-onset pre-eclampsia, enhanced deSUMOylation of HIF1A by SENP3 may in part contribute to increased HIF1A activity and stability found in this pathology.
- High SENP3 expression is associated with stomach neoplasms.
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