Leta i den här bloggen


tisdag 2 juli 2019

SENP3 (17p13.1), SMT3IP1, SSP3, Ulp1, SENP desumoylaaseja

 https://www.ncbi.nlm.nih.gov/gene/26168
Official Symbol
SENP3, provided by HGNC
Official Full Name
SUMO specific peptidase 3, provided by HGNC
Also known as
SSP3; Ulp1; SMT3IP1
Summary
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]
Expression. Ubiquitous expression in testis (RPKM 20.2), brain (RPKM 14.1) and 25 other tissues Se
Preferred Names
sentrin-specific protease 3
Names
SUMO-1-specific protease 3
SUMO1/sentrin/SMT3 specific peptidase 3
sentrin/SUMO-specific protease 3
NM_015670.6NP_056485.2  sentrin-specific protease 3
Conserved Domains (1) summary
pfam02902
Location:400572
Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
 
GeneRIFs: Gene References Into Functions

Inga kommentarer:

Skicka en kommentar