RNF107, UHFR2 (9p24.1) intranukleaaristen polyglutamiiniaggrekaattien hajoittaja

UHFR2
tuman polyglutamiiniaggrekaattien hajoittaja E3 ub-ligaasi,
https://www.ncbi.nlm.nih.gov/gene/115426 

Also known as NIRF; URF2; RNF107; TDRD23

Summary This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

Expression

Ubiquitous expression in bone marrow (RPKM 16.7), lymph node (RPKM 12.5) and 25 other tissues See more

Orthologs

 

Preferred Names

E3 ubiquitin-protein ligase UHRF2

Names

Np95-like ring finger protein

RING finger protein 107

RING-type E3 ubiquitin transferase UHRF2

np95/ICBP90-like RING finger protein

nuclear protein 97

nuclear zinc finger protein NP97

ubiquitin-like PHD and RING finger domain-containing protein 2

ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase

ubiquitin-like, containing PHD and RING finger domains, 2

ubiquitin-like-containing PHD and RING finger domains protein 2

 NM_152896.3 → NP_690856.1  E3 ubiquitin-protein ligase UHRF2

Conserved Domains (6) summary

cd01797
Location:1 → 78

NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF

smart00213
Location:3 → 74

UBQ; Ubiquitin homologues

cd00162
Location:732 → 775

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd15617
Location:346 → 392

PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)

pfam02182
Location:446 → 614

SAD_SRA; SAD/SRA domain

pfam12148
Location:125 → 312

TTD; Tandem tudor domain within UHRF1

Related articles in PubMed

1. Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. Iguchi T, et al. Oncology, 2018. PMID 29909415
2. Loss of UHRF2 expression is associated with human neoplasia, promoter hypermethylation, decreased 5-hydroxymethylcytosine, and high proliferative activity. Lu H, et al. Oncotarget, 2016 Nov 15. PMID 27738314, Free PMC Article
3. Structural basis for hydroxymethylcytosine recognition by the SRA domain of UHRF2. Zhou T, et al. Mol Cell, 2014 Jun 5. PMID 24813944
4. Ubiquitin-like with PHD and ring finger domains 2 is a predictor of survival and a potential therapeutic target in colon cancer. Lu S, et al. Oncol Rep, 2014 Apr. PMID 24573556
5. UHRF2 mRNA expression is low in malignant glioma but silencing inhibits the growth of U251 glioma cells in vitro. Wu TF, et al. Asian Pac J Cancer Prev, 2012. PMID 23244124

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

1. UHRF2 may be a negative regulator of EMT and a novel prognostic biomarker for ESCC.
2. UHRF2 expression is reduced in some leukemia cell lines, this correlates with promoter hypermethylation, and similar UHRF2 methylation profiles are seen in primary human leukemia samples. Thus, UHRF2 and 5hmC are widely present in differentiated human tissues, and UHRF2 protein is poorly expressed or mislocalized in diverse human cancers.
3. Here, we report the complex structure of PCNA and the peptide ((784)NEILQTLLDLFFPGYSK(800)) derived from UHRF2 that contains a PIP box. Structural analysis combined with mutagenesis experiments provide the molecular basis for the recognition of UHRF2 by PCNA via PIP-box.
4. Results show that UHRF2 down-regulates a number of epithelial-mesenchymal transition markers and up-regulates the expression of transcription factors. The study also suggests that UHRF2 play a role in tumor metastasis.
5. TIP60 acted downstream of UHRF2 to regulate H3K9ac and H3K14ac expression.
6. The overexpression of UHRF2 increased the expression of H3K9ac in L02 normal cells (P<0 .01="" 9="" a="" acetylation="" but="" cancer="" cells.="" decreased="" expression="" h3="" hepg2="" histone="" in="" lysine="" of="" the="">
7. study suggests that ZNF618 is a key protein that regulates UHRF2 function as a specific 5hmC reader in vivo.
8. UHRF2 may contribute to the progression of colon carcinogenesis and function as a novel prognostic indicator after curative operation
9. A hydrogen bond between the hydroxyl group of 5hmC and UHRF2-SRA is critical for their preferential binding.
10. UHRF2 is a transcriptional target of E2F, that it directly interacts with E2F1.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Avainproteiini joka säätelee UHRF2 proteiinia on  Sinkkisormi 618. ZNF618. mitä siitä tiedetään?