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tisdag 9 juli 2019

ZBED4 (22q13.33) Verkkokalvon tappien valoreseptoreissa mRNA ZBED4,

 https://www.genenames.org/data/genegroup/#!/group/64

ZBED4 (22q13.33) geeni ilmentyy eniten luuytimessä ja paksusuolessa. Sen mRNA:ta on retinan tapeissa valoreseptoreissa ja  Müllerin gliasoluissa.  Proteiinilla on 1171 aminohappoa ja sen N-tgerminaalisessa domeenissa ilmenee neljä BED tyyppistä  sinkkisormea. C-terminaalissa on lisäksi katalyyttinen aluea,  alfa-helikaalinen domeeni ja imeerisoitumiskohta.

Katson sen neljää BED ZNF domeenia ja niissä olevat  H ja C kombinaatiot ovat seuraavat:
HCCHH, HHCCHH, HHCCCCHH, HCCHCCHH .

 https://www.ncbi.nlm.nih.gov/gene/9889
KUVA: 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606216/figure/pone-0059940-g001/
Official Symbol
ZBED4provided by HGNC
Official Full Name
zinc finger BED-type containing 4provided by HGNC
Expression: Ubiquitous expression in bone marrow (RPKM 4.8), colon (RPKM 4.3) and 25 other tissues See more
Preferred Names
zinc finger BED domain-containing protein 4
Names
zinc finger, BED domain containing 4
 NM_014838.3NP_055653.2  zinc finger BED domain-containing protein 4
 
Conserved Domains (2) summary
pfam02892
Location:118166
zf-BED; BED zinc finger
pfam05699
Location:10881164
Dimer_Tnp_hAT; hAT family C-terminal dimerisation region

FEATURES             Location/Qualifiers
     source          1..1171
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     Protein         1..1171
                     /product="zinc finger BED domain-containing protein 4"
                     /note="zinc finger, BED domain containing 4"
                     /calculated_mol_wt=130192
     Region          118..166
                     /region_name="zf-BED"
                     /note="BED zinc finger; pfam02892"
                     /db_xref="CDD:308506"
     Region          288..336
                     /region_name="zf-BED"
                     /note="BED zinc finger; pfam02892"
                     /db_xref="CDD:308506"
     Region          459..506
                     /region_name="zf-BED"
                     /note="BED zinc finger; pfam02892"
                     /db_xref="CDD:308506"
     Region          561..609
                     /region_name="zf-BED"
                     /note="BED zinc finger; pfam02892"
                     /db_xref="CDD:308506"
     Site            624
                     /site_type="phosphorylation"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="Phosphoserine. {ECO:0000244|PubMed:23186163};
                     propagated from UniProtKB/Swiss-Prot (O75132.2)"
     Region          1088..1164
                     /region_name="Dimer_Tnp_hAT"
                     /note="hAT family C-terminal dimerisation region;
                     pfam05699"
                     /db_xref="CDD:310361"
     CDS             1..1171
                     /gene="ZBED4"
                     /coded_by="NM_014838.3:476..3991"
                     /db_xref="CCDS:CCDS33677.1"
                     /db_xref="GeneID:9889"
                     /db_xref="HGNC:HGNC:20721"
                     /db_xref="MIM:612552"
ORIGIN      
        1 mennlktcpk edgdfvsdki kfkieeeddd gippdslerm dfkseqedmk qtdsggerag
       61 lggtgcsckp pgkylsaese ddygalfsqy sstlydvame avtqsllssr nmssrkkspa
      121 wkhffisprd stkaicmycv kefsrgknek dlstsclmrh vrrahptvli qengsvsavs
      181 sfpspslllp pqpadagdls tilspiklvq kvaskipspd riteesvsvv sseeissdms
      241 vsekcgreea lvgssphlpa lhydepaenl aekslplpks tsgsrrrsav wkhfylspld
      301 nskavcihcm nefsrgkngk dlgtsclirh mwrahraivl qenggtgipp lystpptllp
      361 sllppegels svssspvkpv respsasssp drltedlqsh lnpgdglmed vaafsssddi
      421 geasasspek qqadglsprl fesgaifqqn kkvmkrlkse vwhhfslapm dslkaecryc
      481 gcaisrgkkg dvgtsclmrh lyrrhpevvg sqkgflgasl anspyatlas aesssskltd
      541 lptvvtknnq vmfpvnskkt sklwnhfsic sadstkvvcl hcgrtisrgk kptnlgtscl
      601 lrhlqrfhsn vlktevseta rpsspdtrvp rgtelsgass fddtnekfyd shpvakkits
      661 liaemialdl qpysfvdnvg fnrlleylkp qyslpapsyf srtaipgmyd nvkqiimshl
      721 keaesgvihf tsgiwmsnqt reyltltahw vsfesparpr cddhhcsall dvsqvdcdys
      781 gnsiqkqlec wweawvtstg lqvgitvtdn asigktlneg ehssvqcfsh tvnlivseai
      841 ksqrmvqnll slarkicerv hrspkakekl aelqreyalp qhhliqdvps kwstsfhmle
      901 rlieqkrain emsvecnfre liscdqwevm qsvcralkpf eaasremstq mstlsqvipm
      961 vhilnrkvem lfeetmgidt mlrslkeamv srlsatlhdp ryvfatlldp rykaslftee
     1021 eaeqykqdli relelmnsts edvaashrcd agspskdsaa eenlwslvak vkkkdprekl
     1081 peamvlayle eevlehscdp ltywnlkkas wpglsalavr flgcppsivp seklfntpte
     1141 ngslgqsrlm mehfeklifl kvnlpliyfq y
//
Related articles in PubMed
GeneRIFs: Gene References Into Functions
 

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