https://www.genenames.org/data/genegroup/#!/group/64
BED zinc finger In molecular biology the BED-type zinc finger domain is a protein domain which was named after the Drosophila proteins BEAF and DREF, is found in one or more copies in cellular regulatory factors and transposases from plants, animals and fungi. The BED finger is an about 50 to 60 amino acid residues domain that contains a characteristic motif with two highly conserved aromatic positions, as well as a shared pattern of cysteines and histidines that is predicted to form a zinc finger. As diverse BED fingers are able to bind DNA, it has been suggested that DNA-binding is the general function of this domain. [Source: Wikipedia]
https://en.wikipedia.org/wiki/BED_zinc_finger
9.7. 2019. Suomennosta lähteestä:
ZBED1 , BED- tyyppinen sinkkisormiproteiini. (C-x-C-x-H-x-H)
Muita nimiä ALTE, DREF, TRAMP, hDREF
DNA replikaatioon liittyviin elementtteihin kiinnittyvä faktori
(DNA replication-related element binding factor)
Geeni sijaitsee pseudoautosomaalisella alueella 1 (PAR1) X- ja Y-kromosomissa.Aiemmin se identifioitiin Ac- transposoituvien elementtien kaltaisena. Kuitenkin havaittiin, ettei sillä ollut transposaasi-aktiivisuutta. Myöhemmin osoitettiin, että tämä geenituote paikallistui tumaan ja toimi transkriptiotekijänä. Se sitoutuu DNA-elementteihin, joita on useiden proliferaatioon assosioituvien geenien promoottorialueissa, kuten Histoniin H1, joten sillä lienee osuutta soluproliferaation liittyvien geenien säätelyssä. Vaihtoehtoispleissauksista tulee variantteja, joilla on eri 5`UTR- Geeni ilmentyy munuaisessa ja paksusuolessa eniten.
ZBED1 (Xp22.23 ja Yp11.2.)https://www.ncbi.nlm.nih.gov/gene/9189
- official Symbol
- ZBED1
- Official Full Name
- zinc finger BED-type containing 1
- Also known as
- ALTE; DREF; TRAMP; hDREF
- Summary: This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
- Expression Ubiquitous expression in kidney (RPKM 10.8), colon (RPKM 10.6) and 25 other tissues See more
- Preferred Names
- zinc finger BED domain-containing protein 1, (ZBED1)
- Names
- Ac-like transposable element, (ALTE)
- BED-type zinc finger domain-containing protein 1
- DNA replication-related element binding factor
- dREF homolog
- Conserved Domains (3) summary
-
- pfam02892
Location:23 → 72 - zf-BED; BED zinc finger
- pfam05699
Location:571 → 650 - Dimer_Tnp_hAT; hAT family C-terminal dimerization region. This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.
- pfam14372
Location:412 → 480 - DUF4413; Domain of unknown function (DUF4413)This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.
- pfam02892
ORIGIN 1 menkslessq tdlklvahpr akskvwkyfg fdtnaegCil qwkkiyCriC maqiaysgnt 61 snlsyHlekn Hpeefcefvk snteqmreaf atafsklkpe ssqqpgqdal avkaghgyds 121 kkqqeltaav lgliceglyp asivdeptfk vllktadpry elpsrkyist kaipekygav 181 revilkelae atwcgistdm wrsenqnray vtlaahflgl gapnclsmgs rclktfevpe 241 entaetitrv lyevfiewgi sakvfgattn ygkdivkacs lldvavhmpc lghtfnagiq 301 qafqlpklga llsrcrklve yfqqsavamy mlyekqkqqn vahcmlvsnr vswwgstlam 361 lqrlkeqqfv iagvlvedsn nhhlmlease watieglvel lqpfkqvaem lsasryptis 421 mvkpllhmll nttlniketd skelsmakev iakelsktyq etpeidmfln vatfldpryk 481 rlpflsafer qqvenrvvee akglldkvkd ggyrpaedki fpvpeeppvk klmrtstppp 541 asvinnmlae ifcqtggved qeewhaqvve elsnfksqkv lglnedplkw wsdrlalfpl 601 lpkvlqkywc vtatrvaper lfgsaanvvs akrnrlapah vdeqvflyen arsgaeaepe 661 dqdegewgld qeqvfslgdg vsggffgird ssfl
- Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers. Hansen SV, et al. PLoS One, 2018. PMID 30304065, Free PMC Article
- Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. Yamashita D, et al. J Biol Chem, 2016 May 27. PMID 27068747, Free PMC Article Here, we provide evidence that hDREF possesses small ubiquitin-like modifier (SUMO) ligase activity and can specifically SUMOylate Mi2α, an ATP-dependent DNA helicase in the nucleosome remodeling and deacetylation complex
- hDREF regulates cell proliferation and expression of ribosomal protein genes. Yamashita D, et al. Mol Cell Biol, 2007 Mar. PMID 17220279, Free PMC Article Although ribosomal proteins (RPs) are essential cellular constituents in all living organisms, mechanisms underlying regulation of their gene expression in mammals remain unclear. We have established that 22 out of 79 human RP genes contain sequences similar to the human DREF (DNA replication-related element-binding factor; hDREF) binding sequence (hDRE) within 200-bp regions upstream of their transcriptional start sites. Electrophoretic gel mobility shift assays and chromatin immunoprecipitation analysis indicated that hDREF binds to hDRE-like sequences in the RP genes both in vitro and in vivo. In addition, transient luciferase assays revealed that hDRE-like sequences act as positive elements for RP gene transcription and cotransfection of an hDREF-expressing plasmid was found to stimulate RP gene promoter activity. Like that of hDREF, expression of RP genes is increased during the late G(1) to S phases, and depletion of hDREF using short hairpin RNA-mediated knockdown decreased RP gene expression and cell proliferation in normal human fibroblasts. Knockdown of the RPS6 gene also resulted in impairment of cell proliferation. These data suggest that hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of RP genes.
- Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. Ohshima N, et al. J Biol Chem, 2003 Jun 20. PMID 12663651
- A novel pseudoautosomal human gene encodes a putative protein similar to Ac-like transposases. Esposito T, et al. Hum Mol Genet, 1999 Jan. PMID 9887332
GeneRIFs: Gene References Into Functions
- ZBED1 is not a cell proliferation-associated factor such as Drosophila DREF, and our study adds to the cumulative understanding of the functions of ZBED1 in human cells and tissues.
- These findings identify DREF as a novel adenovirus E1A C terminus binding partner and provide evidence supporting a role for DREF in viral replication.
- expression of hDREF/KIAA0785 may have a role in regulation of human genes related to cell proliferation
- self-association of hDREF via the hATC domain is necessary for its nuclear accumulation and DNA binding.
- hDREF is an important transcription factor for cell proliferation which plays roles in cell cycle-dependent regulation of a number of ribosomal protein genes
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