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tisdag 9 juli 2019

ZBED1 (Xp22.23 ja Yp11.2) , DREF, TRAMP, ALTE. H1- histonin säätelijä. SUMO E3 ligaasi

 https://www.genenames.org/data/genegroup/#!/group/64

 BED zinc finger In molecular biology the BED-type zinc finger domain is a protein domain which was named after the Drosophila proteins BEAF and DREF, is found in one or more copies in cellular regulatory factors and transposases from plants, animals and fungi. The BED finger is an about 50 to 60 amino acid residues domain that contains a characteristic motif with two highly conserved aromatic positions, as well as a shared pattern of cysteines and histidines that is predicted to form a zinc finger. As diverse BED fingers are able to bind DNA, it has been suggested that DNA-binding is the general function of this domain. [Source: Wikipedia]

 https://en.wikipedia.org/wiki/BED_zinc_finger

 9.7. 2019. Suomennosta lähteestä:

 ZBED1 , BED- tyyppinen sinkkisormiproteiini. (C-x-C-x-H-x-H)

Muita nimiä ALTE, DREF, TRAMP, hDREF

DNA replikaatioon liittyviin elementtteihin  kiinnittyvä faktori 
(DNA replication-related element binding factor)

Geeni sijaitsee pseudoautosomaalisella alueella 1 (PAR1) X- ja Y-kromosomissa.Aiemmin se identifioitiin  Ac- transposoituvien elementtien kaltaisena. Kuitenkin  havaittiin,  ettei sillä ollut transposaasi-aktiivisuutta. Myöhemmin  osoitettiin, että tämä geenituote paikallistui tumaan ja toimi transkriptiotekijänä.  Se sitoutuu DNA-elementteihin, joita on useiden  proliferaatioon assosioituvien geenien promoottorialueissa, kuten Histoniin H1, joten  sillä lienee osuutta  soluproliferaation liittyvien geenien säätelyssä. Vaihtoehtoispleissauksista tulee  variantteja, joilla on eri  5`UTR-  Geeni ilmentyy munuaisessa  ja paksusuolessa eniten.

ZBED1  (Xp22.23 ja Yp11.2.)
https://www.ncbi.nlm.nih.gov/gene/9189
official Symbol
ZBED1
Official Full Name
zinc finger BED-type containing 1
Also known as
ALTE; DREF; TRAMP; hDREF
Summary: This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]
Expression Ubiquitous expression in kidney (RPKM 10.8), colon (RPKM 10.6) and 25 other tissues See more
Preferred Names
zinc finger BED domain-containing protein 1, (ZBED1)
Names
Ac-like transposable element, (ALTE)
BED-type zinc finger domain-containing protein 1
DNA replication-related element binding factor
dREF homolog
NM_001171135.1NP_001164606.1  zinc finger BED domain-containing protein 1
Conserved Domains (3) summary
pfam02892
Location:2372
zf-BED; BED zinc finger
pfam05699
Location:571650
Dimer_Tnp_hAT; hAT family C-terminal dimerization region. This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.
pfam14372
Location:412480
DUF4413; Domain of unknown function (DUF4413)This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.
ORIGIN      
        1 menkslessq tdlklvahpr akskvwkyfg fdtnaegCil qwkkiyCriC maqiaysgnt
       61 snlsyHlekn Hpeefcefvk snteqmreaf atafsklkpe ssqqpgqdal avkaghgyds
      121 kkqqeltaav lgliceglyp asivdeptfk vllktadpry elpsrkyist kaipekygav
      181 revilkelae atwcgistdm wrsenqnray vtlaahflgl gapnclsmgs rclktfevpe
      241 entaetitrv lyevfiewgi sakvfgattn ygkdivkacs lldvavhmpc lghtfnagiq
      301 qafqlpklga llsrcrklve yfqqsavamy mlyekqkqqn vahcmlvsnr vswwgstlam
      361 lqrlkeqqfv iagvlvedsn nhhlmlease watieglvel lqpfkqvaem lsasryptis
      421 mvkpllhmll nttlniketd skelsmakev iakelsktyq etpeidmfln vatfldpryk
      481 rlpflsafer qqvenrvvee akglldkvkd ggyrpaedki fpvpeeppvk klmrtstppp
      541 asvinnmlae ifcqtggved qeewhaqvve elsnfksqkv lglnedplkw wsdrlalfpl
      601 lpkvlqkywc vtatrvaper lfgsaanvvs akrnrlapah vdeqvflyen arsgaeaepe
      661 dqdegewgld qeqvfslgdg vsggffgird ssfl

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