COPS1 , GPS1 (17q25.3), SGN1

https://www.ncbi.nlm.nih.gov/gene/2873

Official Symbol

GPS1provided by HGNC

Official Full Name

G protein pathway suppressor 1provided by HGNC

Also known as

CSN1; SGN1; COPS1

Summary

This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016]

Expression

Ubiquitous expression in kidney (RPKM 28.1), testis (RPKM 27.1) and 25 other tissues See more

Orthologs mouse all

Preferred Names

COP9 signalosome complex subunit 1

Names

JAB1-containing signalosome subunit 1

1. NM_001321089.2 → NP_001308018.1  COP9 signalosome complex subunit 1 isoform 3
   

   ORIGIN      
           1 mplpvqvfnl qqpassvsgs ggaesqdrmr dssapssass svtdlyctph ssrsdlvlpg
          61 tagdfslsas lsactllyeg avepmqidvd pqedpqnapd vnyvvenpsl dleqyaasys
         121 glmrierlqf iadhcptlrv ealkmalsfv qrtfnvdmye eihrklseat rsslrelqna
         181 pdaipesgve ppaldtawve atrkkallkl ekldtdlkny kgnsikesir rghddlgdhy
         241 ldcgdlsnal kcysrardyc tsakhvinmc lnvikvsvyl qnwshvlsyv skaestpeia
         301 eqrgerdsqt qailtklkca aglaelaark ykqaakclll asfdhcdfpe llspsnvaiy
         361 gglcalatfd rqelqrnvis sssfklflel epqvrdiifk fyeskyascl kmldemkdnl
         421 lldmylaphv rtlytqirnr aliqyfspyv sadmhrmaaa fnttvaaled eltqlilegl
         481 isarvdshsk ilyardvdqr sttfeksllm gkefqrraka mmlraavlrn qihvksppre
         541 gsqgeltpan sqsrmstnm
   //

   
   
   
   
   Status: REVIEWED

   Source sequence(s)

   AC135056, AK026610, BP306851

   Conserved Domains (2) summary

   pfam01399
   Location:392 → 496

   PCI; PCI domainThis domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).

   pfam10602
   Location:195 → 377

   RPN7; 26S proteasome subunit RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is  involved in the ATP-dependent degradation of ubiquitinated proteins.

 

Related articles in PubMed

1. UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis. Dubois EL, et al. Oncol Rep, 2016 May. PMID 26986008
2. CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1. Tsuge T, et al. Protein Cell, 2011 May. PMID 21604193, Free PMC Article
3. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma. Feber A, et al. Cancer Res, 2016 Aug 15. PMID 27325650, Free PMC Article
4. Altered expression of COP9 signalosome proteins in preeclampsia. Cayli S, et al. Gynecol Endocrinol, 2012 Jun. PMID 22103747
5. CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation. Chun Y, et al. J Biol Chem, 2013 Sep 20. PMID 23926101, Free PMC Article
6. Purification of the COP9 signalosome complex and binding partners from human T cells. Stotland A, et al. OMICS, 2012 Jun. PMID 22414063, Free PMC Article

See all (84) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. We identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1
2. CSN1 appears to play a role not only in DNA repair but also in UV-induced apoptosis.
3. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
4. An increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.  The presumptive factors that are released by the preeclamptic placenta to cause maternal disease are less well known. The constitutive photomorphogenic-9 (COP9) signalosome (CSN) complex, a multifunctional protein complex involved in modulating signal transduction, gene transcription, and protein stability in cells. Although the roles of most CSN components in early embryonic development have been studied, their role in preeclamptic human placentas is not known. Thus, this study was aimed to show the localization and the protein expression of CSN1 and CSN5 in normal and preeclamptic placenta. The distribution and the protein expression of CSN1 and CSN5 were analyzed in normal (n: 15) and preeclamptic (n: 15) human placenta by using immunohistochemistry (IHC) and Western blotting. CSN1 and CSN5 were mainly localized in the vascular endothelium, syncytiotrophoblast, stromal and Hofbauer cells in normal and preeclamptic placentas. However, a stronger immunoreactivity and protein expression for CSN1 and CSN5 were observed in preeclamptic placentas compared to normal term placentas. Western blotting of the tissue extracts confirmed the IHC results. Our results suggest that an increased level of CSN1 and CSN5 as an important part of the ubiquitin proteasome system (UPS) might be associated with the pathophysiology of preeclampsia.
5. CSN1 inhibits c-Jun phosphorylation without affecting its protein stability.
6. The N-terminal half of CSN1/GPS1 is required to repress c-fos expression and to inhibit AP-1 and SRE transactivation, while the C-terminal half allows integration of the protein into the COP9 signalosome.

Erityishuomio: UV dependent phosphorylation

https://www.ncbi.nlm.nih.gov/pubmed/27173435