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tisdag 16 juli 2019

USP10 deubikitinaasi hinosäätää NOTC funktiota stabiloimalla NICD1 (16q24.1) . USP10 stabiloi PTEN.

https://www.ncbi.nlm.nih.gov/gene/9100
USP10provided by HGNC
Official Full Name
ubiquitin specific peptidase 10
Also known as
UBPO
Summary
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Expression Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues See more
Related articles in PubMed

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