SENP7 (3q12.3) , SUSP2, SENP desumoylaasi

https://www.ncbi.nlm.nih.gov/gene/57337

Summary

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]

ExpressionUbiquitous expression in endometrium (RPKM 9.0), lymph node (RPKM 7.6) and 25 other tissues

Preferred Names

sentrin-specific protease 7

Names

SUMO-1-specific protease 2

SUMO1/sentrin specific peptidase 7

sentrin/SUMO-specific protease SENP7

1. NM_001077203.3 → NP_001070671.1  sentrin-specific protease 7
   C-terminal:  several q, even qqq.
   

Related articles in PubMed

1. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Bawa-Khalfe T, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23045645, Free PMC Article
2. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. Lima CD, et al. J Biol Chem, 2008 Nov 14. PMID 18799455, Free PMC Article
3. Differential regulation of sentrinized proteins by a novel sentrin-specific protease. Gong L, et al. J Biol Chem, 2000 Feb 4. PMID 10652325
4. Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7. Ji P, et al. Biochem Biophys Res Commun, 2018 Jul 7. PMID 29777712
5. Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7. Alegre KO, et al. J Biol Chem, 2011 Oct 14. PMID 21878624, Free PMC Article

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

 

GeneRIFs: Gene References Into Functions

1. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis.
2. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
3. deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair.
4. differential splicing of the SENP7 regulates either tumor suppression or progression
5. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.
6. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2