ZBED3 (5q13.3), BED. domeenin omaava ZNF, axiinin kanssa inrteraktion tekevä proteiini,

 https://www.genenames.org/data/genegroup/#!/group/64

BED ZNF rakenne peruskaava   C-x-C-x-H-x-H.

(Suomennosta) tämä ZBED3-geeni kuuluu siihen geeniluokkaan, joka muodostui  humaani AT DNA transpositiosta ja koodaa säätelyllisiä proteiineja. Tämä geeni on säätynyt ylös keuhkosyöpäkudoksessa, jossa  koodautunut proteiini aiheuttaa beta-kateniinin akkumuloitumista ja  vauhdittaa keuhkosyöpäsolun invasoitumista,  joten tämä geeni  on otettava huomioon.
 Lisäksi geenin koodaamaa  proteiinia voi erittyä ja se osallistuu insuliiniresistenssiin. Geeniä ilmenee rasvakudoksessa  ja munuaisessa eniten.

https://www.ncbi.nlm.nih.gov/gene/84327

Official Symbol

ZBED3

Official Full Name

zinc finger BED-type containing 3

Summary: This gene belongs to a class of genes that arose through hAT DNA transposition and that encode regulatory proteins. This gene is upregulated in lung cancer tissues, where the encoded protein causes an accumulation of beta-catenin and enhanced lung cancer cell invasion. In addition, the encoded protein can be secreted and be involved in resistance to insulin. [provided by RefSeq, Jul 2016]

Expression Ubiquitous expression in fat (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues See more Orthologs  mouse all.

Preferred Names

zinc finger BED domain-containing protein 3

Names

2610005H11Rik

axin-interacting protein

zinc finger, BED domain containing 3

NM_001329564.2 → NP_001316493.1  zinc finger BED domain-containing protein 3

Conserved Domains (1) summary

smart00614
Location:47 → 100

ZnF_BED; BED zinc finger

  DNA-binding domain in chromatin-boundary-element-binding proteins and transposases

ORIGIN      
        1 mrsgepactm dqarglddaa arggqcpglg paptptppgr lgapyseawg yfHlapgrpg
       61 HpsgHwatCr lCgeqvgrgp gfHagtsalw rHlrsaHrre lessgagssp paapcppppg
      121 paaapegdwa rlleqmgala vrgsrrerel errelaveqg eralerrrra lqeeeraaaq
      181 arrelqaere alqarlrdvs rregalgwap aappplkddp egdrdgcvit kvll
//

x6-H-x7-H-x3-H-x3-C-xx-C-x10-H- x8-H-x4-H-x3

Related articles in PubMed

(Suom.  1). Ihmisen synoviaalinesteen  mesenkymaalisissa  kantasoluissa indusoituu  ruston muodostus  eli  chondrogeneesi  lncRNA ZBED3-AS1 vaikutuksesta  ( ZBED3 geenin pitkän ei-koodaavan RNA:n antisense-1 johdannaisen  vaikutuksesta). Ihmisen synoviaalinesteestä (SF) peräisin olevat  mesenkymaalit kantasolut (MSC)   (SFMSC) omaavat   erinomaisen kyvyn  ruston induktioon ja ne ovat lupaava  soluperusteinen strategia  nivelruston korjaamiseen. Monet pitkät ei-koodaavat RNA:t (lncRNA)  säätelevät  mesenkymaalisten  kantasolujen kondrogeneesiä. Tutkijat tekivät oletuksen, että  divergoituva   lncRNA ZBED-AS1, joka kiinnittyy paikallisesti  kromatiiniin, voisi edistää zbed3;  ilmentymistä, mikä  on uusi axiinin kanssa interaktion tekevä proteiini, joka  aktivoi  kondrogeneesiin kuuluvaa Wnt/beta-kateniini-signalointia  Kuitenkaan ei  ollut aiemmin tiedossa, miten ZBED-AS1- toimisi  SFMSC-soluissa. Tutkijat  saivat selville, että ZBED-AS1 edistää kondrogeneesiä ja saattoi   suoraan lisätä zbed3 ilmentymistä .
 Wnt-estäjä DKK1  pystyi  poistamaan ZBED3-AS1:n  kondrogeneesiä stimuloivan vaikutuksen  Täten voitiin osoittaa uuden lncRNA:nm  ZBED-AS1,   osuus  SFMSC-kondrogeneesissä  ja näin saatetaan  parantaa osteoartriitin hoitoa.

1. The LncRNA ZBED3-AS1 induces chondrogenesis of human synovial fluid mesenchymal stem cells. Ou F, et al. Biochem Biophys Res Commun, 2017 May 27. PMID 28431932. Human synovial fluid-derived mesenchymal stem cells (SFMSCs) have great potential for cartilage induction and are promising for cell-based strategies for articular cartilage repair. Many long non-coding RNAs (lncRNAs) regulate chondrogenesis of MSCs. We hypothesized that the divergent lncRNA ZBED3-AS1, which binds locally to chromatin, could promote the expression of zbed3, a novel Axin-interacting protein that activates Wnt/β-catenin signaling, involved in chondrogenesis. However, the function of ZBED3-AS1 in SFMSCs is unclear. In this study, the expression, biological function, and roles of ZBED3-AS1 in SFMSC chondrogenesis were examined by multilineage differentiation, flow cytometry, and gain-of-function studies. We found that ZBED3-AS1 promotes chondrogenesis. Furthermore, ZBED3-AS1 could directly increase zbed3 expression. Finally, the wnt-inhibitor DKK1 could reverse the stimulatory effect of ZBED3-AS1 on chondrogenesis. These findings demonstrate the role of a new lncRNA, ZBED3-AS1, in SFMSC chondrogenesis and may improve osteoarthritis treatment.  
2. Circulating Zbed3 Levels in Subjects With and Without Metabolic Syndrome. Hu W, et al. Metab Syndr Relat Disord, 2017 Jun. PMID 28346859  BACKGROUND: Zinc-finger BED domain-containing 3 (Zbed3) is a member of the zinc-finger domain protein superfamily. Recent studies have shown that Zbed3 is associated with insulin resistance and type 2 diabetes mellitus. However, no report has demonstrated the association of Zbed3 with metabolic syndrome (MetS) in humans. The purpose of this study is to examine the association between Zbed3 and MetS in a cross-sectional study. METHODS:
   We conducted a cross-sectional study of a Chinese population, including 167 non-MetS subjects and 144 newly diagnosed MetS (nMetS) patients. Circulating Zbed3 levels were examined by enzyme-linked immunosorbent assay. The relationship between circulating Zbed3 levels and the components of MetS was assessed. RESULTS:
   Circulating Zbed3 levels were significantly higher in nMetS patients than in non-MetS subjects (134.6 ± 32.1 vs. 106.5 ± 26.1 ng/L, P < 0.01). Circulating Zbed3 correlated positively with markers of adiposity (waist circumference, P < 0.01). It also correlated with glucose and lipid parameters (increasing fasting blood glucose and triglycerides and decreasing high-density lipoprotein cholesterol, all P < 0.01) and blood pressure (elevating systolic blood pressure and diastolic blood pressure, both P < 0.01) and inflammatory marker (elevating tumor necrosis factor alpha, P < 0.01). The relative risks for MetS showed significant elevation with an increase in Zbed3 quartiles. Circulating levels of Zbed3 were progressively elevated with an increased number of components of MetS. CONCLUSIONS:
   These data suggest that Zbed3 may correlate with the pathogenesis of MetS in humans.
   
3. Zbed3 contributes to malignant phenotype of lung cancer via regulating β-catenin and P120-catenin 1. Fan C, et al. Mol Carcinog, 2015 Jun. PMID 25263389
4. Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted protein associated with insulin resistance in humans. Jia Y, et al. J Intern Med, 2014 May. PMID 24283382Zbed3 was detected in an analysis of in vitro secretion in both conditioned medium and lysates of HEK-293T cells transfected with an overexpressed vector. In a clinical study, there were significantly higher levels of circulating Zbed3 in IGT and nT2DM relative to NGT. Zbed3 levels were positively correlated with BMI, WHR, FAT%, blood pressure, FBG, TG, HbA1c, FIns and HOMA-IR and inversely correlated with HDL-C. Increasing levels of Zbed3 were independently associated with IGT and T2DM. Zbed3 mRNA and protein in muscle and fat were significantly elevated in both db/db mice and T2DM patients. Moreover, there was a concentration-dependent effect of glucose on Zbed3 release, whereas insulin exhibited an inhibitory effect on Zbed3 levels. Zbed3 suppressed insulin-induced IR and Akt phosphorylation. CONCLUSIONS: These results suggest that the Zbed3 protein may be a cytokine associated with insulin resistance in humans that is influenced by glucose and insulin levels.
   
5. Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. Chen T, et al. J Biol Chem, 2009 Mar 13. PMID 19141611, Free PMC Article

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Zbed3 concentrations were significantly higher in metabolic syndrome patients compared with healthy subjects. Circulating Zbed3 concentrations were associated with glucose and lipid parameters, markers of adiposity, and blood pressure.
2. Finally, the wnt-inhibitor DKK1 could reverse the stimulatory effect of ZBED3-AS1 on chondrogenesis. These findings demonstrate the role of a new lncRNA, ZBED3-AS1, in SFMSC chondrogenesis and may improve osteoarthritis treatment.
3. results suggest that Zbed3 may contribute to lung cancer cell invasion through regulating beta-catenin and p120ctn-1 and may be a promissing cancer marker in non-small cell lung cancer
4. results suggest that the Zbed3 protein may be a cytokine associated with insulin resistance in humans that is influenced by glucose and insulin levels.
5. Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
6. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation.

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