COP9 signalosomista edelleen: DDA1 (damaged DNA binding protein assoc. 1 )(19p13.11), PCIA-1

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2720933/

J Cell Sci. 2009 Apr 1; 122(7): 1035–1044.

Published online 2009 Mar 18. doi: 10.1242/jcs.043539

PMCID: PMC2720933

PMID: 19295130

An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases

Michael Hans Olma,^1,* Ma

rcia Roy,^2,*‡ et aliae.

Dda1 . Mikä tämä on ?

https://www.ncbi.nlm.nih.gov/gene/79016

DDA1 DET1 and DDB1 associated 1 [ Homo sapiens (human) ]

Gene ID: 79016, updated on 17-Jun-2019

Official Symbol

DDA1, provided by HGNC

Official Full Name

DET1 and DDB1 associated 1, provided by HGNC

Also known as

PCIA1; C19orf58

Expression

Ubiquitous expression in placenta (RPKM 7.7), brain (RPKM 6.3) and 25 other tissues See more

Orthologs

mouse all

Preferred Names

DET1- and DDB1-associated protein 1

Names

PCIA-1

cross-immune reaction antigen PCIA1

placenta cross-immune reaction antigen 1

mRNA and Protein(s)

1. NM_024050.6 → NP_076955.1  DET1- and DDB1-associated protein 1
   See identical proteins and their annotated locations for NP_076955.1
   
   

   Conserved Domains (1) summary

   pfam10172
   Location:3 → 65

   DDA1; Det1 complexing ubiquitin ligaseDDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system.

Related articles in PubMed

1. [Searching for genes interacting with human PCIA1 gene by using the bacterial two-hybrid system]. Li ZM, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2007 Jun. PMID 17557237
2. DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle. Cheng L, et al. J Cell Mol Med, 2017 Aug. PMID 28211159, Free PMC Article
3. Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase. Gao S, et al. J Biol Chem, 2017 Mar 3. PMID 28087699, Free PMC Article
4. DDA1 promotes stage IIB-IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling. Zhao S, et al. Oncotarget, 2016 Apr 12. PMID 26942699, Free PMC Article
5. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. Srivastava S, et al. PLoS Pathog, 2008 May 9. PMID 18464893, Free PMC Article

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

1. surveyed the spectrum of G protein coupling of dDA1 and Damb, and we confirmed that both receptors can couple to Gs to stimulate cAMP synthesis
2. The results indicate that DDA1 promotes lung ca AbstractLung cancer is globally widespread and associated with high morbidity and mortality. DDA1 (DET1 and DDB1 associated 1) was first discovered and registered in the GenBank database by our colleagues. DDA1, an evolutionarily conserved gene, might have significant functions. Recent reports have demonstrated that DDA1 is linked to the ubiquitin-proteasome pathway and facilitates the degradation of target proteins. However, the function of DDA1 in lung cancer was previously unknown. This study aimed to investigate whether DDA1 contributes to tumorigenesis and progression of lung cancer. We found that the expression of DDA1 in normal lung cells and tissue was significantly lower than that in lung cancer and was associated with poor prognosis. DDA1 overexpression promoted proliferation of lung tumour cells and facilitated cell cycle progression in vitro and subcutaneous xenograft tumour progression in vivo. Mechanistically, this was associated with the regulation of S phase and cyclins including cyclin D1/D3/E1. These results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression. Therefore, DDA1 may be a potential novel target for lung cancer treatment, and a biomarker for tumour prognosis.
   ncer progression, potentially through promoting cyclins and cell cycle progression.
3. Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway.
4. the c-Abl non-receptor kinase phosphorylates DDB1 at residue Tyr-316 to recruit a small regulatory protein, DDA1, leading to increased substrate ubiquitination
5. Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with cullin-RING E3 ligases complexes.
6. PCIA1 gene expression correlates with tumor formation, invasion and metastasis

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