COPS4 (4q21.22) , CSN4, SGN4, CO9 alayksikkö 4. Omaa RPN5 jakson (samanlainen kuin proteosomilla 26S)

COPS4

Official Symbol

COPS4provided by HGNC

Official Full Name

COP9 signalosome subunit 4provided by HGNC

Also known as

CSN4; SGN4

Summary

This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Expression

Ubiquitous expression in testis (RPKM 26.4), brain (RPKM 21.8) and 25 other tissues See more

Ortholog

mouse 

Preferred Names

COP9 signalosome complex subunit 4

Names

COP9 constitutive photomorphogenic homolog subunit 4

COP9 constitutive photomorphogenic-like protein subunit 4

JAB1-containing signalosome subunit 4

signalosome subunit 4

testis tissue sperm-binding protein Li 42a

1. NM_001258006.2 → NP_001244935.1  COP9 signalosome complex subunit 4 isoform 2
   See identical proteins and their annotated locations for NP_001244935.1
   
   Status: REVIEWED

   Description

   Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

   Source sequence(s)

   AK094238, BC009292

   Consensus CDS

   CCDS58909.1

   UniProtKB/Swiss-Prot

   Q9BT78

   Related

   ENSP00000425976.1, ENST00000509093.5

   Conserved Domains (1) summary

   COG5071
   Location:71 → 337

   RPN5; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

     ##Evidence-Data-START##
            Transcript exon combination :: AK094238.1, SRR1803613.382316.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..352
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.22"
     Protein         1..352
                     /product="COP9 signalosome complex subunit 4 isoform 2"
                     /note="COP9 signalosome complex subunit 4; signalosome
                     subunit 4; JAB1-containing signalosome subunit 4; COP9
                     constitutive photomorphogenic homolog subunit 4; COP9
                     constitutive photomorphogenic-like protein subunit 4;
                     testis tissue sperm-binding protein Li 42a"
                     /calculated_mol_wt=40066
     Region          <71 ..337="" b="" note="26S proteasome regulatory complex component
                     [Posttranslational modification, protein turnover,
                     chaperones]; COG5071" region_name="RPN5">
                     /db_xref="CDD:227403"
     CDS             1..352
                     /gene="COPS4"
                     /gene_synonym="CSN4; SGN4"
                     /coded_by="NM_001258006.2:43..1101"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS58909.1"
                     /db_xref="GeneID:51138"
                     /db_xref="HGNC:HGNC:16702"
                     /db_xref="MIM:616008"
ORIGIN      
        1 maaavrqdla qlmnssgshk dlagkyrqil ekaiqlsgae qlealkafve amvnenvslv
       61 isrqlltdfc thlpnlpdst akeiyhftle kiqprvisfe eqvasirqhl asiyekeedw
      121 rnaaqvlvgi pletgqkqyn vdykletylk iarlyleddd pvqaeayinr asllqnestn
      181 eqlqihykvc yarvldyrrk fieaaqryne lsyktivhes erlealkhal hctilasagq
      241 qrsrmlatlf kdercqqlaa ygilekmyld riirgnqlqe faamlmphqk attadgssil
      301 draviehnll sasklynnit feelgallei paakhekpcq rgisrsnhfv sk
//

Related articles in PubMed

1. COP9 signalosome revisited: a novel mediator of protein degradation. Schwechheimer C, et al. Trends Cell Biol, 2001 Oct. PMID 11567875
2. Aberrant expression of signaling-related proteins 14-3-3 gamma and RACK1 in fetal Down syndrome brain (trisomy 21). Peyrl A, et al. Electrophoresis, 2002 Jan. PMID 11824616
3. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. Cohen H, et al. J Biol Chem, 2000 Dec 15. PMID 10991940
4. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. Naumann M, et al. J Biol Chem, 1999 Dec 10. PMID 10585392
5. COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells. Bhansali M, et al. Mol Endocrinol, 2014 Jun. PMID 24725084, Free PMC Article

See all (99) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. CSN4 silencing decreases CSN5 protein levels and suggest that the CSN4 effects on sGCA1 and p53 proteins are mediated by CSN5.
2. Identified is a novel-binding partner of torsin A, the subunit 4 (CSN4) of CSN signalosome.
3. Level in fetal Down syndrome brain found to be comparable to that of controls.

Submit: New GeneRIF Correction