https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606216/figure/pone-0059940-g001/
KUVA:
Schematic representation of ZBED, ZBEDX and C7ORF29 proteins.
Coloured
symbols correspond to different protein domains. Numbers represent
estimated domain boundaries in amino acid positions. Roman numerals are
used to indicate multiple BED ZNF domains within ZBED proteins.
The housefly
(Musca domestica) Hermes transposon serves as a reference for the schematics of human (Homo sapiens) ZBED1-4 and 6, western clawed frog (Xenopus tropicalis)
ZBEDX, and human Buster1 (ZBED5). C7ORF29 is present in mammals and is
syntenic with ZBEDX but lacks the N-terminal domain and part of the
catalytic and alpha-helical domains (human and chimpanzee (Pan troglodytes) are also further truncated at the dimerization domain for C7ORF29).
TARKEMPI FYLOGENETIIKKA ZBED- sinkkisormille! Otan jatkossa vain esiin Pubmed artikkelien tietoa, joka koskee ihmisen ZBED- geenejä.
Fylogeneettinen jaottelu on Ac- juuresta seuraavat: ZBED- 4, -6,-3,-2, ja -1.
Buster- juuresta ZBED5 ja oletettavia geenejä läytyy sieltä myös ZBED -7, -8 ja -9.
PLoS One. 2013; 8(3): e59940.
Published online 2013 Mar 22. doi: 10.1371/journal.pone.0059940
PMCID: PMC3606216
PMID: 23533661
ZBED Evolution: Repeated Utilization of DNA Transposons as Regulators of Diverse Host Functions
Marc Robinson-Rechavi, Editor
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