COPS3(17p11.2) , CSN3, SGN3. Onkogeeni,kinaasi. Oma JAB1:n , PINT motiivin. COP9 alayksikkö.

https://www.ncbi.nlm.nih.gov/gene/8533

Official Symbol

COPS3provided by HGNC

Official Full Name

COP9 signalosome subunit 3provided by HGNC

Also known as

CSN3; SGN3

Summary

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Expression

Ubiquitous expression in testis (RPKM 49.1), bone marrow (RPKM 38.5) and 25 other tissues See more

Orthologs mouse all

 

Preferred Names

COP9 signalosome complex subunit 3

Names

COP9 complex subunit 3

COP9 constitutive photomorphogenic homolog subunit 3

JAB1-containing signalosome subunit 3

signalosome subunit 3

FEATURES             Location/Qualifiers
     source          1..403
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p11.2"
     Protein         1..403
                     /product="COP9 signalosome complex subunit 3 isoform 2"
                     /note="COP9 complex subunit 3; JAB1-containing signalosome
                     subunit 3; COP9 signalosome complex subunit 3; COP9
                     constitutive photomorphogenic homolog subunit 3"
                     /calculated_mol_wt=45596
     Region          239..342 ayhe 
                     /region_name="PCI"
                     /note="PCI domain; pfam01399"
                     /db_xref="CDD:307522"

PCI domain
This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).
     CDS             1..403
                     /gene="COPS3"
                     /gene_synonym="CSN3; SGN3"
                     /coded_by="NM_001199125.1:131..1342"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS56022.1"
                     /db_xref="GeneID:8533"
                     /db_xref="HGNC:HGNC:2239"
                     /db_xref="MIM:604665"
ORIGIN      
        1 mtqlcelink sgellaknls hldtvlgald vqehslgvla vlfvkfsmps vpdfetlfsq
       61 vqlfistcng ehiryatdtf aglchqltna lverkqplrg igilkqaidk mqmntnqlts
      121 ihadlcqlcl lakcfkpalp yldvdmmdic kengaydakh flcyyyyggm iytglknfer
      181 alyfyeqait tpamavshim lesykkyilv slillgkvqq lpkytsqivg rfikplsnay
      241 helaqvystn npselrnlvn khsetftrdn nmglvkqcls slykkniqrl tktfltlslq
      301 dmasrvqlsg pqeaekyvlh miedgeifas inqkdgmvsf hdnpekynnp amlhnidqem
      361 lkcielderl kamdqeitvn pqfvqksmgs qeddsgnkps sys

 

 

Related articles in PubMed

1. Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis of osteosarcoma through autophagy. Zhang F, et al. J Exp Clin Cancer Res, 2018 Jul 3. PMID 29970115, Free PMC Article
2. Overexpression of COPS3 promotes clear cell renal cell carcinoma progression via regulation of Phospho-AKT(Thr308), Cyclin D1 and Caspase-3. Hong Y, et al. Exp Cell Res, 2018 Apr 15. PMID 29477618
3. Integrated analysis of gene expression and genomic aberration data in osteosarcoma (OS). Xiong Y, et al. Cancer Gene Ther, 2015 Nov. PMID 26427513
4. Identification of novel candidate oncogenes in chromosome region 17p11.2-p12 in human osteosarcoma. Both J, et al. PLoS One, 2012. PMID 22292074, Free PMC Article
5. Inhibition of Csn3 expression induces growth arrest and apoptosis of hepatocellular carcinoma cells. Yu YS, et al. Cancer Chemother Pharmacol, 2012 May. PMID 22237956

See all (107) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. these data reveal a novel function of COPS3 in the regulation of autophagy and highlight the relationship between autophagy and metastasis in osteosarcoma cells.
2. COPS3 may be a new potential target of clear cell renal cell carcinoma.
3. Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.
4. this study demonstrates Csn3 as an oncogene that regulates the tumorigenesis process in hepatocellular carcinoma (HCC) cells.
5. of the COPS3 gene might have important roles in metastasis of osteosarcoma cells.

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