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GNL3 , nuklestemiini

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GNL3
Identifiers
Aliases	GNL3, C77032, E2IG3, NNP47, NS, G protein nucleolar 3
External IDs	MGI: 1353651 HomoloGene: 56670 GeneCards: GNL3
[hide]Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.1 Start 52,681,156 bp[1] End 52,694,492 bp[1]
[show]Gene location (Mouse)
[hide]RNA expression pattern More reference expression data
[show]Gene ontology
Orthologs
Species	Human	Mouse
Entrez	26354	30877
Ensembl	ENSG00000163938	ENSMUSG00000042354
UniProt	Q9BVP2	Q8CI11
RefSeq (mRNA)	NM_206826 NM_014366 NM_206825	NM_153547 NM_178846
RefSeq (protein)	NP_055181 NP_996561 NP_996562	NP_705775
Location (UCSC)	Chr 3: 52.68 – 52.69 Mb	Chr 3: 31.01 – 31.02 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.^[5][6][7] It is found within the nucleolus that binds p53.^[8] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.^[8] It is a marker for many stem cells and cancer cells.^[9]

Interactions

GNL3 has been shown to interact with Mdm2^[10] and P53.^[6]