Ubikitiinin kaltainen Diubikitiini, UBD (6p22.1) Ubikitiini D, FAT19, GABBR1, UBD-3,

https://www.ncbi.nlm.nih.gov/gene/10537
Tämä   kaksi ubikitiinin kaltaisia (Ubl)  jaksoja sisältävä diubikitiini  UBD, jolla on nimi FAT10 , Se voi tietysti olla normaali kudosspesifinen ubikitiinityyppi. Löydettiin 1997 dendriittisoluista ja B-soluista ja se vaikutti toimivan ubikitiinin tavoin. Kertyvä tieto osoittaa  sitä esiintyvän onkologiankin puolella.

FAT10; UBD-3; GABBR1

Summary

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017]

Expression

Biased expression in lymph node (RPKM 113.8), appendix (RPKM 64.9) and 10 other tissues See more

Preferred Names

ubiquitin D

Names

diubiquitin

ubiquitin-like protein FAT10

 

 

( Peptide history, structure:

  https://www.ncbi.nlm.nih.gov/protein/NP_006389.2

 

Conserved Domains (2) summary

smart00213
Location:8 → 79

UBQ; Ubiquitin homologues

cl00155
Location:104 → 165

UBQ; Ubiquitin-like proteins

 

Related articles in PubMed

1. Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism. Cappadocia L, et al. Chem Rev, 2018 Feb 14. PMID 28234446, Free PMC Article
2. The ubiquitin-like modifier FAT10 in cancer development. Aichem A, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27393295
3. The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense. Basler M, et al. Mol Immunol, 2015 Dec. PMID 25983082
4. Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying β-catenin degradation. Yuan R, et al. Cancer Res, 2014 Sep 15. PMID 25056121
5. Increased FAT10 expression is related to poor prognosis in pancreatic ductal adenocarcinoma. Sun GH, et al. Tumour Biol, 2014 Jun. PMID 24492942

See all (92) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. FAT10 promotes tumor proliferation by directly stabilizing Survivin protein in breast cancer cells.
2. our data suggest that FAT10 was upregulated via retinoic acid-induced protein I and NF-kappaB during H5N1 avian influenza virus infection. And the upregulated FAT10 promoted H5N1 viral replication by inhibiting type I IFN.
3. we show how FAT10 stabilizes the translation elongation factor eEF1A1, which contributes to cancer cell proliferation
4. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage.
5. this study revealed a novel function of LMO2 involving in the regulatory hierarchy of UBA6-USE1-FAT10ylation pathway by targeting the E1 enzyme UBA6.
6. unlike ISG15, ubiquitin and FAT10 are conjugated to a similar degree to newly translated and pre-existing proteins.
7. We also found that FAT10 may act its oncogenic functions through regulating HOXB9. Collectively, the results suggested that FAT10 may be a novel therapeutic target for osteosarcoma patients
8. High expression of FAT10 is associated with glioma.
9. Study demonstrates how the coordinated interplay of RIG-I, TRIM25, and FAT10 regulate the antiviral innate inflammatory response.
10. Data suggest that ubiquitin D (UBD) provides a negative feedback on cytokine-induced activation of the endoplasmic reticulum to nucleus signaling 1 (IRE1alpha)/c-Jun N-terminal kinase (JNK) pro-apoptotic pathway in cytokine-exposed beta cells.