RNF 182 (Kr. 6p23)
Protein 247
aminohappoa.
19..69
RING-HC-RNF182
20..67 RING-HC
finger (C3HC4 tyyppi-)
184..204, TM region
211..231, TM region.
Pub Med Gene:
TM-RNF ryhmän
kuuluva E3 ubikitiiniligaasi.
RNF182 appears to be a pro-apoptotic factor. RNF182 was identified as
a brain-specific E3 enzyme that targets ATP6V0C, a component of
vacuolar ATPase, for proteasomal degradation [144].
Its mRNA levels are elevated in the brain with Alzheimer disease and
in NT2 neuron cells undergoing stress-induced apoptosis. Increased
RNF182 expression makes the neuron cells highly sensitive to
stress-induced apoptosis [144].
Although the downregulation of ATP6V0C is unlikely to contribute to
neuronal apoptosis, it may facilitate the regulation of pH
homeostasis in neuronal cells.
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