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fredag 15 juni 2018

RNF 182 (Kr.6p23) (TM-RNF perheen jäsen) . Proapoptoottinen, esiintyy keskushermostossa

RNF 182 (Kr. 6p23)

Protein 247 aminohappoa.
19..69 RING-HC-RNF182
20..67 RING-HC finger (C3HC4 tyyppi-)
184..204, TM region
211..231, TM region.
Pub Med Gene: 


TM-RNF ryhmän kuuluva E3 ubikitiiniligaasi.

RNF182 appears to be a pro-apoptotic factor. RNF182 was identified as a brain-specific E3 enzyme that targets ATP6V0C, a component of vacuolar ATPase, for proteasomal degradation [144]. 
Its mRNA levels are elevated in the brain with Alzheimer disease and in NT2 neuron cells undergoing stress-induced apoptosis. Increased RNF182 expression makes the neuron cells highly sensitive to stress-induced apoptosis [144]. Although the downregulation of ATP6V0C is unlikely to contribute to neuronal apoptosis, it may facilitate the regulation of pH homeostasis in neuronal cells.

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