RNF167 (Kr.17p13.2)
- Also known as LP2254; RING105; 5730408C10Rik
- Summary RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
- Expression Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues See more Orthologs mouse all
Related articles in PubMed
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RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking. Deshar R, et al. FEBS J, 2016 Dec. PMID 27808481
-
Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. van Dijk JR, et al. Biochem J, 2014 Apr 1. PMID 24387786
-
Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Lussier MP, et al. Proc Natl Acad Sci U S A, 2012 Nov 20. PMID 23129617, Free PMC Article
-
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. Yamada HY, et al. Oncogene, 2006 Mar 2. PMID 16314844, Free PMC Article
-
Goliath
family E3 ligases regulate the recycling endosome pathway via VAMP3
ubiquitylation. Yamazaki Y, et al. EMBO J, 2013 Feb 20.
PMID 23353890, Free
PMC Article
See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?
Preferred Names
- E3 ubiquitin-protein ligase RNF167
- Names
- RING-type E3 ubiquitin transferase RNF167
Conserved Domains (2) summary
- cd02123
Location:20 → 170 - PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
-
pfam13639
Location:228 → 272 - zf-RING_2; Ring finger domain
Peptide history and precursor sequence of isoform
https://www.ncbi.nlm.nih.gov/protein/NP_001307285.1
E3 ubiquitin-protein
ligase RNF167 isoform a precursor [Homo sapiens]
NCBI Reference Sequence: NP_001307285.1Identical Proteins FASTA Graphics
LOCUS NP_001307285 350 aa linear PRI 01-JUN-2018
DEFINITION E3 ubiquitin-protein ligase RNF167 isoform a precursor [Homo
sapiens].
ACCESSION NP_001307285 XP_011522090
VERSION NP_001307285.1
DBSOURCE REFSEQ: accession NM_001320356.1
KEYWORDS RefSeq.
SOURCE Homo sapiens (human)
ORGANISM Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
REFERENCE 1 (residues 1 to 350)
AUTHORS Deshar R, Moon S, Yoo W, Cho EB, Yoon SK and Yoon JB.
TITLE RNF167 targets Arl8B for degradation to regulate lysosome
positioning and endocytic trafficking
JOURNAL FEBS J. 283 (24), 4583-4599 (2016)
PUBMED 27808481
REMARK GeneRIF: Data indicate that E3 ubiquitin-protein ligase RNF167
ubiquitinates Arl8B at the lysine residue K141 and reduces the
level of the ADP-ribosylation factor-like 8B Arl8B protein.
REFERENCE 2 (residues 1 to 350)
AUTHORS Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J,
Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L,
Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L,
Grundberg E, Waldenberger M, Richards JB, Mohney RP, Milburn MV,
John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ,
Gieger C, Kastenmuller G, Spector TD and Soranzo N.
CONSRTM Multiple Tissue Human Expression Resource (MuTHER) Consortium
TITLE An atlas of genetic influences on human blood metabolites
JOURNAL Nat. Genet. 46 (6), 543-550 (2014)
PUBMED 24816252
REFERENCE 3 (residues 1 to 350)
AUTHORS van Dijk JR, Yamazaki Y and Palmer RH.
TITLE Tumour-associated mutations of PA-TM-RING ubiquitin ligases
RNF167/RNF13 identify the PA domain as a determinant for endosomal
localization
JOURNAL Biochem. J. 459 (1), 27-36 (2014)
PUBMED 24387786
REMARK GeneRIF: Point mutations are characterized in the RING domain of
RNF167 and RNF13.
REFERENCE 4 (residues 1 to 350)
AUTHORS Yamazaki Y, Schonherr C, Varshney GK, Dogru M, Hallberg B and
Palmer RH.
TITLE Goliath family E3 ligases regulate the recycling endosome pathway
via VAMP3 ubiquitylation
JOURNAL EMBO J. 32 (4), 524-537 (2013)
PUBMED 23353890
REMARK GeneRIF: mutation of the Godzilla ubiquitylation target lysines on
VAMP3 abrogates the formation of enlarged endosomes induced by
either Godzilla or RNF167.
REFERENCE 5 (residues 1 to 350)
AUTHORS Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M,
Youle RJ, Nicoll RA and Roche KW.
TITLE Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic
transmission
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 109 (47), 19426-19431 (2012)
PUBMED 23129617
REMARK GeneRIF: RNF167 is a selective regulator of AMPAR-mediated
neurotransmission.
REFERENCE 6 (residues 1 to 350)
AUTHORS Wang AG, Yoon SY, Oh JH, Jeon YJ, Kim M, Kim JM, Byun SS, Yang JO,
Kim JH, Kim DG, Yeom YI, Yoo HS, Kim YS and Kim NS.
TITLE Identification of intrahepatic cholangiocarcinoma related genes by
comparison with normal liver tissues using expressed sequence tags
JOURNAL Biochem. Biophys. Res. Commun. 345 (3), 1022-1032 (2006)
PUBMED 16712791
REFERENCE 7 (residues 1 to 350)
AUTHORS Yamada HY and Gorbsky GJ.
TITLE Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel
ubiquitin ligase RING105
JOURNAL Oncogene 25 (9), 1330-1339 (2006)
PUBMED 16314844
REFERENCE 8 (residues 1 to 350)
AUTHORS Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X,
Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X,
Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S and Gu J.
TITLE Large-scale cDNA transfection screening for genes related to cancer
development and progression
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 101 (44), 15724-15729 (2004)
PUBMED 15498874
REMARK Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE 9 (residues 1 to 350)
AUTHORS Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee
NH, Kirkness EF, Weinstock KG, Gocayne JD, White O et al.
TITLE Initial assessment of human gene diversity and expression patterns
based upon 83 million nucleotides of cDNA sequence
JOURNAL Nature 377 (6547 Suppl), 3-174 (1995)
PUBMED 7566098
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AL521425.3, DB055876.1, HY016013.1, AK025329.1 and AI350817.1.
On Feb 20, 2016 this sequence version replaced XP_011522090.1.
Summary: RNF167 is an E3 ubiquitin ligase that interacts with TSSC5
(SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM
602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky,
2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008].
Transcript Variant: This variant (2) differs in the 5' UTR compared
to variant 1. Variants 1, 2, 3, 4, 5, 6, and 7 all encode the same
isoform (a).
##Evidence-Data-START##
CDS exon combination :: SRR1163657.573104.1, SRR1163655.155742.1
[ECO:0000331]
RNAseq introns :: single sample supports all introns
SAMEA1965299, SAMEA1966682 [ECO:0000348]
##Evidence-Data-END##
FEATURES Location/Qualifiers
source 1..350
/organism="Homo sapiens"
/db_xref="taxon:9606"
/chromosome="17"
/map="17p13.2"
Protein 1..350
/product="E3 ubiquitin-protein ligase RNF167 isoform a
precursor"
/EC_number="2.3.2.27"
/note="E3 ubiquitin-protein ligase RNF167; RING-type E3
ubiquitin transferase RNF167"
/calculated_mol_wt=35888
sig_peptide 1..24
/inference="COORDINATES: ab initio prediction:SignalP:4.0"
/calculated_mol_wt=2429
Region 20..170
/region_name="PA_C_RZF_like"
/note="PA_C-RZF_ like: Protease-associated (PA) domain
C_RZF-like. This group includes various PA
domain-containing proteins similar to C-RZF (chicken
embryo RING zinc finger) protein. These proteins contain a
C3H2C3 RING finger. C-RZF is expressed in embryo...;
cd02123"
/db_xref="CDD:239038"
mat_peptide 25..350
/product="E3 ubiquitin-protein ligase RNF167"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H6Y7.1)"
/calculated_mol_wt=35888
Site 120..122
/site_type="other"
/note="PA/protease or protease-like domain interface
[polypeptide binding]"
/db_xref="CDD:239038"
Site 174..194
/site_type="transmembrane region"
/experiment="experimental evidence, no additional details
recorded"
/note="propagated from UniProtKB/Swiss-Prot (Q9H6Y7.1)"
Region 228..272
/region_name="zf-RING_2"
/note="Ring finger domain; pfam13639"
/db_xref="CDD:290367"
Site order(230,233,248,250,253,256,268,271)
/site_type="other"
/note="cross-brace motif"
/db_xref="CDD:238093"
CDS 1..350
/gene="RNF167"
/gene_synonym="5730408C10Rik; LP2254; RING105"
/coded_by="NM_001320356.1:501..1553"
/note="isoform a precursor is encoded by transcript
variant 2"
/db_xref="CCDS:CCDS11060.1"
/db_xref="GeneID:26001"
/db_xref="HGNC:HGNC:24544"
/db_xref="MIM:610431"
ORIGIN
1 mhpaafplpv vvaavlwgaa ptrglirats dhnasmdfad lpalfgatls qeglqgflve
61 ahpdnacspi appppapvng svfiallrrf dcnfdlkvln aqkagygaav vhnvnsnell
121 nmvwnseeiq qqiwipsvfi gersseylra lfvyekgarv llvpdntfpl gyylipftgi
181 vgllvlamga vmiarciqhr krlqrnrltk eqlkqipthd yqkgdqydvc aicldeyedg
241 dklrvlpcah ayhsrcvdpw ltqtrktcpi ckqpvhrgpg dedqeeetqg qeegdegepr
301 dhpasertpl lgssptlpts fgslapaplv fpgpstdppl sppsspvilv
//
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