RNF34 (12q24.31), CARP-1 E3 ubikitiiniligaasi, Kaspaasisäätelijä-1, RIF, hRFI

RNF- proteiineista: CARP E3 ubikitiiniligaasit 

Löysin tällaisen ryhmän kuin CARP- E3 uikitiiniligaasit ja huomaan  että ainkin CARP1 on RNF joukkoa, joka minulla on listassa jo. .  Otan siitä tietoa tähän suomentamatta vielä. Löydän kaksi CARP- geeniä.

https://www.ncbi.nlm.nih.gov/pubmed/17986872

RNF34 (12q24.31) , CARP-1, RFI, RIF, RIFF, hRFI

Also known as

RFI; RIF; RIFF; hRFI; CARP1; CARP-1

Summary

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Expression

Ubiquitous expression in testis (RPKM 15.4), lymph node (RPKM 13.4) and 25 other tissues See more

Orthologs

mouse all Related articles in PubMed

1. Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. Konishi T, et al. Mol Cancer Ther, 2005 May. PMID 15897238
2. Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence. Sasaki S, et al. J Exp Clin Cancer Res, 2004 Sep. PMID 15595643
3. The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway. Zhang R, et al. Cell Physiol Biochem, 2014. PMID 25012219
4. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. Sasaki S, et al. Oncogene, 2002 Jul 25. PMID 12118383
5. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Wei P, et al. Mol Cell Biol, 2012 Jan. PMID 22064484, Free PMC Article
   

See all (25) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1).
2. Data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner.
3. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified.
4. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death.
5. hRFI may act as an oncogenic molecule affecting the apoptotic pathway
6. a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI)
   

Submit: New GeneRIF Correction

Related articles in PubMed

1. Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells. Konishi T, et al. Mol Cancer Ther, 2005 May. PMID 15897238
2. Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence. Sasaki S, et al. J Exp Clin Cancer Res, 2004 Sep. PMID 15595643
3. The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway. Zhang R, et al. Cell Physiol Biochem, 2014. PMID 25012219
4. Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer. Sasaki S, et al. Oncogene, 2002 Jul 25. PMID 12118383
5. RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1α and modulates brown fat cell metabolism. Wei P, et al. Mol Cell Biol, 2012 Jan. PMID 22064484, Free PMC Article
   

See all (25) citations in PubMed
See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

1. Data indicate that E3 ligase RNF34 is associated with nucleotide-binding oligomerization domain-containing protein 1 (NOD1).
2. Data indicate AE induces caspase-8-mediated activation of mitochondrial death pathways by decreasing the stability of CARP mRNAs in a p53-independent manner.
3. The previously unknown small molecule inhibitor-dependent interaction of Cbeta1 with the cell cycle and apoptosis regulatory protein-1 was verified.
4. CARPs together with MDM2 enhance p53 degradation, thereby inhibiting p53-mediated cell death.
5. hRFI may act as an oncogenic molecule affecting the apoptotic pathway
6. a novel gene, hRFI, preferentially expressed in esophageal cancer (hRFI)
   

Submit: New GeneRIF Correction

Preferred Names

E3 ubiquitin-protein ligase RNF34

Names

FYVE-RING finger protein MOMO

RING finger protein RIFF

RING-type E3 ubiquitin transferase RNF34

caspase regulator CARP1

caspases-8 and -10-associated RING finger protein 1

human RING finger homologous to inhibitor of apoptosis protein

ring finger protein 34, E3 ubiquitin protein ligase

2)

Conserved domaions isoform 2

Summary

cd15769
Location:59 → 105

FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins

cd16706
Location:324 → 362

RING-HC_CARP1; RING finger, HC subclass, found in caspases-8 and -10-associated RING finger protein 1 (CARP1) and similar proteins

Peptide sequence and history, isoform 2

(Geeni löytynyt 2002 , japanilaiset tiedemiehet).

https://www.ncbi.nlm.nih.gov/protein/NP_079402.2