UBC6, Kr.6q15
https://ravidlab.huji.ac.il/sites/default/files/styles/os_files_xxlarge/public/ravidlab/files/erad.jpg?m=1456952355&itok=vDeC-Hp1
https://www.ncbi.nlm.nih.gov/protein/NP_057105.2
ubiquitin-conjugating
enzyme E2 J1 [Homo sapiens]
NCBI Reference Sequence: NP_057105.2Identical Proteins FASTA Graphics
LOCUS NP_057105 318 aa linear PRI 09-MAY-2018 DEFINITION ubiquitin-conjugating enzyme E2 J1 [Homo sapiens]. ACCESSION NP_057105 NP_057420 VERSION NP_057105.2 DBSOURCE REFSEQ: accession NM_016021.2 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. REFERENCE 1 (residues 1 to 318) AUTHORS Hagiwara M, Ling J, Koenig PA and Ploegh HL. TITLE Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e JOURNAL Mol. Cell 63 (5), 753-767 (2016) PUBMED 27570074 REMARK GeneRIF: Post-transcriptional regulation of glycoprotein quality control in the endoplasmic reticulum is controlled by the UBC6e. REFERENCE 2 (residues 1 to 318) AUTHORS Zhong Y, Shen H, Wang Y, Yang Y, Yang P and Fang S. TITLE Identification of ERAD components essential for dislocation of the null Hong Kong variant of alpha-1-antitrypsin (NHK) JOURNAL Biochem. Biophys. Res. Commun. 458 (2), 424-428 (2015) PUBMED 25660456 REFERENCE 3 (residues 1 to 318) AUTHORS El Khouri E, Le Pavec G, Toledano MB and Delaunay-Moisan A. TITLE RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR) JOURNAL J. Biol. Chem. 288 (43), 31177-31191 (2013) PUBMED 24019521 REFERENCE 4 (residues 1 to 318) AUTHORS Sato T, Sako Y, Sho M, Momohara M, Suico MA, Shuto T, Nishitoh H, Okiyoneda T, Kokame K, Kaneko M, Taura M, Miyata M, Chosa K, Koga T, Morino-Koga S, Wada I and Kai H. TITLE STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein JOURNAL Mol. Cell 47 (1), 99-110 (2012) PUBMED 22607976 REFERENCE 5 (residues 1 to 318) AUTHORS Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM and Lehner PJ. TITLE HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation JOURNAL Proc. Natl. Acad. Sci. U.S.A. 108 (5), 2034-2039 (2011) PUBMED 21245296 REMARK GeneRIF: data support a physiological role for HRD1 and UBE2J1 in the homeostatic regulation of MHC class I assembly and expression REFERENCE 6 (residues 1 to 318) AUTHORS Wu CJ, Conze DB, Li X, Ying SX, Hanover JA and Ashwell JD. TITLE TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination JOURNAL EMBO J. 24 (10), 1886-1898 (2005) PUBMED 15861135 REFERENCE 7 (residues 1 to 318) AUTHORS Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J and Beck S. TITLE The DNA sequence and analysis of human chromosome 6 JOURNAL Nature 425 (6960), 805-811 (2003) PUBMED 14574404 REFERENCE 8 (residues 1 to 318) AUTHORS Lenk U, Yu H, Walter J, Gelman MS, Hartmann E, Kopito RR and Sommer T. TITLE A role for mammalian Ubc6 homologues in ER-associated protein degradation JOURNAL J. Cell. Sci. 115 (Pt 14), 3007-3014 (2002) PUBMED 12082160 REFERENCE 9 (residues 1 to 318) AUTHORS Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y and Takahashi R. TITLE An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin JOURNAL Cell 105 (7), 891-902 (2001) PUBMED 11439185 REFERENCE 10 (residues 1 to 318) AUTHORS Lester D, Farquharson C, Russell G and Houston B. TITLE Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6 JOURNAL Biochem. Biophys. Res. Commun. 269 (2), 474-480 (2000) PUBMED 10708578 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF058850.1, BC013973.1, AF151834.1, AJ420578.1 and AJ420522.1. On or before Feb 14, 2005 this sequence version replaced NP_057420.2, NP_057105.1. Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.27293.1, SRR1660809.112491.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..318
/gene="UBE2J1" /gene_synonym="CGI-76; HSPC153; HSPC205; HSU93243; NCUBE-1; NCUBE1; UBC6; UBC6E; Ubc6p" /coded_by="NM_016021.2:332..1288" /db_xref="CCDS:CCDS5021.1" /db_xref="GeneID:51465" /db_xref="HGNC:HGNC:17598" /db_xref="MIM:616175" ORIGIN 1 metrynlksp avkrlmkeaa elkdptdhyh aqplednlfe whftvrgppd sdfdggvyhg 61 rivlppeypm kppsiillta ngrfevgkki clsisghhpe twqpswsirt allaiigfmp 121 tkgegaigsl dytpeerral akksqdfcce gcgsamkdvl lplksgsdss qadqeakela 181 rqisfkaevn ssgktisesd lnhsfsltdl qddipttfqg atastsyglq nssaasfhqp 241 tqpvakntsm sprqrraqqq sqrrlstspd viqghqprdn htdhggsavl iviltlalaa 301 lifrriylan eyifdfel //
Related articles in PubMed
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Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. Hagiwara M, et al. Mol Cell, 2016 Sep 1. PMID 27570074, Free PMC Article
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A role for mammalian Ubc6 homologues in ER-associated protein degradation. Lenk U, et al. J Cell Sci, 2002 Jul 15. PMID 12082160
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Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Kim BW, et al. Mol Endocrinol, 2003 Dec. PMID 12933904
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Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. Lester D, et al. Biochem Biophys Res Commun, 2000 Mar 16. PMID 10708578
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Analysis
of CFTR folding and degradation in transiently transfected cells.
Grove DE, et al. Methods Mol Biol, 2011. PMID 21594788,
Free
PMC Article
See citations in PubMed for homologs of this gene provided by HomoloGene
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